About DENN domain-containing protein 5B
DENN domain-containing protein 5B (DENND5B) is a protein
from Homo sapiens identified by UniProt accession
Q6ZUT9, 1274 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | DENN domain-containing protein 5B |
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| UniProt accession | Q6ZUT9 |
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| Gene | DENND5B |
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| Organism | Homo sapiens |
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| Length | 1274 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (74)
Diseases linked to this target (Open Targets).
- body height · score 0.36
- electrocardiography · score 0.32
- creatinine measurement · score 0.30
- PHF-tau measurement · score 0.30
- self reported educational attainment · score 0.29
- Abnormality of refraction · score 0.29
- age at first sexual intercourse measurement · score 0.25
- mathematical ability · score 0.24
- intelligence · score 0.23
- schizophrenia · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZUT9-F1 | alphafold | PREDICTED | 76.35 | — |
Amino-acid sequence (1274 residues)
MSGSCAAPGP GSGSSPAACR FAHYFVLCGI DADSGLEPDE LAGENFDQSP LRRTFKSKVL AHYPQNIEWN PFDQDAVNML CMPKGLSFRT QTDNKDPQFH SFIITREDGS RTYGFVLTFY EEVTSKQICT AMQTLYQMHN AEHYSSVYAS SSCSMDSLAS SLDEGDTTSL LKLQRYNSYD ISRDTLYVSK SICLITPLPF MQACKKFLIQ LYKAVTSQQP PPLPLESYIH NILYEVPLPP PGRSLKFYGV YEPVICQRPG PSELPLSDYP LREAFELLGL ENLVQVFTCV LLEMQILLYS QDYQRLMTVA EGITTLLFPF QWQHVYVPIL PASLLHFLDA PVPYLMGLQS KEGTDRSKLE LPQEANLCFV DIDNHFIELP EEFPQFPNKV DFIQELSEVL VQFGIPPEGS LHCSESTSKL KNMVLKDLVN DKKNGNVCTN NISMYELLKG NETIARLQAL AKRTGVAVEK MDLSASLGEK DKDLKLHCEE AELRDYQLNV QLREVFANRF TQMFADYEAF VIQTAQDMES WLTNREQMQN FDKASFLSDQ PEPYLPFLSR FIETQMFATF IDNKIMSQWE EKDPLLRVFD TRIDKIRLYN VRAPTLRTSI YQKCSTLKEA AQSIEQRLMK MDHTAIHPHL LDMKIGQGKY EQGFFPKLQS DVLATGPTSN NRWVSRSATA QRRKERLRQH SEHVGLDNDL REKYMQEARS LGKNLRQPKL SDLSPAVIAQ TNCKFVEGLL KECRMKTKRM LVEKMGHEAV ELGHGEANIT GLEENTLIAS LCDLLERIWS HGLQVKQGKS ALWSHLIQFQ DREEKQEHLA ESPVALGPER RKSDSGVMLP TLRVSLIQDM RHIQNMSEIK TDVGRARAWI RLSLEKKLLS QHLKQLLSNQ PLTKKLYKRY AFLRCEEERE QFLYHLLSLN AVDYFCFTSV FTTIMIPYRS VIIPIKKLSN AIITSNPWIC VSGELGDTGV MQIPKNLLEM TFECQNLGKL TTVQIGHDNS GLLAKWLVDC VMVRNEITGH TYRFPCGRWL GKGIDDGSLE RILIGELMTS ASDEDLVKQC RTPPQQKSPT TARRLSITSL TGKNNKPNAG QIQEGIGEAV NNIVKHFHKP EKERGSLTVL LCGENGLVAA LEQVFHHGFK SARIFHKNVF IWDFIEKVVA YFETTDQILD NEDDVLIQKS SCKTFCHYVN AINTAPRNIG KDGKFQILVC LGTRDRLLPQ WIPLLAECPA ITRMYEESAL LRDRMTVNSL IRILQTIQDF TIVLEGSLIK GVDV
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