About TOG array regulator of axonemal microtubules protein 2
TOG array regulator of axonemal microtubules protein 2 (TOGARAM2) is a protein
from Homo sapiens identified by UniProt accession
Q6ZUX3, 1019 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | TOG array regulator of axonemal microtubules protein 2 |
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| UniProt accession | Q6ZUX3 |
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| Gene | TOGARAM2 |
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| Organism | Homo sapiens |
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| Length | 1019 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- deafness · score 0.26
- hearing loss, autosomal recessive · score 0.26
- neurofibrillary tangles measurement · score 0.22
- cataract · score 0.13
- ferritin measurement · score 0.11
- polycythemia vera · score 0.08
- HbA1c measurement · score 0.07
- urate measurement · score 0.07
- breast carcinoma · score 0.06
- estrogen-receptor negative breast cancer · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZUX3-F1 | alphafold | PREDICTED | 60.93 | — |
Amino-acid sequence (1019 residues)
MGTRDDVPEA KVLVPVAVYC GSIPRTSAGP RVLPPGSINS SLPHGEGSLQ PEPRALLNNE EPSQLLRGLG QLGGLKLDTP SKGWQARNGH PRNLRALSLG DQPLVLLPSP ESEANSVARD TIQIKDKLKK RRLSEGLAAS SRASLDPGGG PQGVPLHSTI PRATSQRLLR VPRPMPLIQS IPTTPEASGV KEKGLDLPGS IPGPHELRPG AQEAQISWQY LHCNDEKMQK SLGAIVIPPI PKARTVAATP SRVPGSLPSP LPPGQGVLTG LRAPRTRLAR GSGPREKTPA SLEPKPLASP IRDRPAAAKK PALPFSQSAP TLTAFSFDCA REACPPLKEE DQKEIGTKIQ VTISKSAREK MQLKQMKEME LLRRLEEPRT GQELTSQCLG SQRAFMKEGL LPLRGSGTLS VPTRLSGPCR NDVSIILRKW ASRASLPSIP ISRQEPRFAR HASANSLPAV LTLGSPEWEE EEEMDLRACK ELRPFSNPEL GLRDALQCLN SSDWQMKEKG LVSIQRLAAC HSEVLTGKLH DVCLVVTGEV TNLRSKVSHL AISTLGDLFQ ALKKNMDQEA EEIARCLLQK MADTNEFIQR AAGQSLRAMV ENVTLARSLV VLTSAGVYHR NPLIRKYAAE HLSAVLEQIG AEKLLSGTRD STDMLVHNLV RLAQDSNQDT RFYGRKMVNI LMANTKFDAF LKQSLPSYDL QKVMAAIKQQ GIEDNDELPS AKGRKVLRSL VVCENGLPIK EGLSCNGPRL VGLRSTLQGR GEMVEQLREL TRLLEAKDFR SRMEGVGQLL ELCKAKTELV TAHLVQVFDA FTPRLQDSNK KVNQWALESF AKMIPLLRES LHPMLLSIII TVADNLNSKN SGIYAAAVAV LDAMVESLDN LCLLPALAGR VRFLSGRAVL DVTDRLAVLV ASVYPRKPQA VERHVLPILW HFLNTATRNG TLPGPSGNIR GVVCRLSRSL QEHMGSRLLD FAASQPKHVL KTLQELLDSE SLGGSRKATD RGVAPDSKTT GSSYPFQLD
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