About Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 (NYAP1) is a protein
from Homo sapiens identified by UniProt accession
Q6ZVC0, 841 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 |
|---|
| UniProt accession | Q6ZVC0 |
|---|
| Gene | NYAP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 841 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.24
- platelet count · score 0.22
- hematocrit · score 0.21
- platelet component distribution width · score 0.21
- hemoglobin measurement · score 0.21
- monocyte count · score 0.17
- self reported educational attainment · score 0.16
- platelet crit · score 0.15
- family history of Alzheimer’s disease · score 0.12
- heel bone mineral density · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZVC0-F1 | alphafold | PREDICTED | 48.40 | — |
Amino-acid sequence (841 residues)
MNLLYRKTKL EWRQHKEEEA KRSSSKEVAP AGSAGPAAGQ GPGVRVRDIA SLRRSLRMGF MTMPASQEHT PHPCRSAMAP RSLSCHSVGS MDSVGGGPGG ASGGLTEDSS TRRPPAKPRR HPSTKLSMVG PGSGAETPPS KKAGSQKPTP EGRESSRKVP PQKPRRSPNT QLSVSFDESC PPGPSPRGGN LPLQRLTRGS RVAGDPDVGA QEEPVYIEMV GDVFRGGGRS GGGLAGPPLG GGGPTPPAGA DSDSEESEAI YEEMKYPLPE EAGEGRANGP PPLTATSPPQ QPHALPPHAH RRPASALPSR RDGTPTKTTP CEIPPPFPNL LQHRPPLLAF PQAKSASRTP GDGVSRLPVL CHSKEPAGST PAPQVPARER ETPPPPPPPP AANLLLLGPS GRARSHSTPL PPQGSGQPRG ERELPNSHSM ICPKAAGAPA APPAPAALLP GPPKDKAVSY TMVYSAVKVT THSVLPAGPP LGAGEPKTEK EISVLHGMLC TSSRPPVPGK TSPHGGAMGA AAGVLHHRGC LASPHSLPDP TVGPLTPLWT YPATAAGLKR PPAYESLKAG GVLNKGCGVG APSPMVKIQL QEQGTDGGAF ASISCAHVIA SAGTPEEEEE EVGAATFGAG WALQRKVLYG GRKAKELDKV EDGARAWNGS AEGPGKVERE DRGPGTSGIP VRSQGAEGLL ARIHHGDRGG SRTALPIPCQ TFPACHRNGD FTGGYRLGRS ASTSGVRQVV LHTPRPCSQP RDALSQPHPA LPLPLPLPPQ PARERDGKLL EVIERKRCVC KEIKARHRPD RGLCKQESMP ILPSWRRGPE PRKSGTPPCR RQHTVLWDTA I
Explore Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets