About UPF0606 protein KIAA1549L
UPF0606 protein KIAA1549L (KIAA1549L) is a protein
from Homo sapiens identified by UniProt accession
Q6ZVL6, 1849 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | UPF0606 protein KIAA1549L |
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| UniProt accession | Q6ZVL6 |
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| Gene | KIAA1549L |
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| Organism | Homo sapiens |
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| Length | 1849 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (43)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.38
- cup-to-disc ratio measurement · score 0.37
- Ocular pain · score 0.31
- peripheral vascular disease · score 0.25
- ventral hernia · score 0.13
- atypical teratoid rhabdoid tumor · score 0.04
- uncombable hair syndrome · score 0.04
- Griscelli disease type 1 · score 0.03
- Griscelli disease · score 0.03
- Griscelli syndrome type 3 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZVL6-F1 | alphafold | PREDICTED | 44.34 | — |
Amino-acid sequence (1849 residues)
MDHTASQNAQ DLIGIPHLGV SGSSTKWHSE LSPTEGPHSA GSSTPGFLSP MAELSHPSPP PPALGSLLQL PDGSPSWSML EVASGPASTQ QIKAGVPGRV HNGVSLPTFK NTETATHEAE PPLFQTAESG AIEMTSRKLA SATANDSANP LHLSAAPENS RGPALSAEHT SSLVPSLHIT TLGQEQAILS GAVPASPSTG TADFPSILTF LQPTENHASP SPVPEMPTLP AEGSDGSPPA TRDLLLSSKV PNLLSTSWTF PRWKKDSVTA ILGKNEEANV TIPLQAFPRK EVLSLHTVNG FVSDFSTGSV SSPIITAPRT NPLPSGPPLP SILSIQATQT VFPSLGFSST KPEAYAAAVD HSGLPASASK QVRASPSSMD VYDSLTIGDM KKPATTDVFW SSLSAETGSL STESIISGLQ QQTNYDLNGH TISTTSWETH LAPTAPPNGL TSAADAIKSQ DFKDTAGHSV TAEGFSIQDL VLGTSIEQPV QQSDMTMVGS HIDLWPTSNN NHSRDFQTAE VAYYSPTTRH SVSHPQLQLP NQPAHPLLLT SPGPTSTGSL QEMLSDGTDT GSEISSDINS SPERNASTPF QNILGYHSAA ESSISTSVFP RTSSRVLRAS QHPKKWTADT VSSKVQPTAA AAVTLFLRKS SPPALSAALV AKGTSSSPLA VASGPAKSSS MTTLAKNVTN KAASGPKRTP GAVHTAFPFT PTYMYARTGH TTSTHTAMQG NMDTASGLLS TTYLPRKPQA MHTGLPNPTN LEMPRASTPR PLTVTAALTS ITASVKATRL PPLRAENTDA VLPAASAAVV TTGKMASNLE CQMSSKLLVK TVLFLTQRRV QISESLKFSI AKGLTQALRK AFHQNDVSAH VDILEYSHNV TVGYYATKGK LVYLPAVVIE MLGVYGVSNV TADLKQHTPH LQSVAVLASP WNPQPAGYFQ LKTVLQFVSQ ADNIQSCKFA QTMEQRLQKA FQDAERKVLN TKSNLTIQIV STSNASQAVT LVYVVGNQST FLNGTVASSL LSQLSAELVG FYLTYPPLTI AEPLEYPNLD ISETTRDYWV ITVLQGVDNS LVGLHNQSFA RVMEQRLAQL FMMSQQQGRR FKRATTLGSY TVQMVKMQRV PGPKDPAELT YYTLYNGKPL LGTAAAKILS TIDSQRMALT LHHVVLLQAD PVVKNPPNNL WIIAAVLAPI AVVTVIIIII TAVLCRKNKN DFKPDTMINL PQRAKPVQGF DYAKQHLGQQ GADEEVIPVT QETVVLPLPI RDAPQERDVA QDGSTIKTAK STETRKSRSP SENGSVISNE SGKPSSGRRS PQNVMAQQKV TKEEARKRNV PASDEEEGAV LFDNSSKVAA EPFDTSSGSV QLIAIKPTAL PMVPPTSDRS QESSAVLNGE VNKALKQKSD IEHYRNKLRL KAKRKGYYDF PAVETSKGLT ERKKMYEKAP KEMEHVLDPD SELCAPFTES KNRQQMKNSV YRSRQSLNSP SPGETEMDLL VTRERPRRGI RNSGYDTEPE IIEETNIDRV PEPRGYSRSR QVKGHSETST LSSQPSIDEV RQQMHMLLEE AFSLASAGHA GQSRHQEAYG SAQHLPYSEV VTSAPGTMTR PRAGVQWVPT YRPEMYQYSL PRPAYRFSQL PEMVMGSPPP PVPPRTGPVA VASLRRSTSD IGSKTRMAES TGPEPAQLHD SASFTQMSRG PVSVTQLDQS ALNYSGNTVP AVFAIPAANR PGFTGYFIPT PPSSYRNQAW MSYAGENELP SQWADSVPLP GYIEAYPRSR YPQSSPSRLP RQYSQPANLH PSLEQAPAPS TAASQQSLAE NDPSDAPLTN ISTAALVKAI REEVAKLAKK QTDMFEFQV
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