TOM1-like protein 2 (TOM1L2)

About TOM1-like protein 2

TOM1-like protein 2 (TOM1L2) is a protein from Homo sapiens identified by UniProt accession Q6ZVM7, 507 residues long. MolForge cross-references it against 0 known binders and 225 disease associations.

Target properties

Protein name	TOM1-like protein 2
UniProt accession	Q6ZVM7
Gene	TOM1L2
Organism	Homo sapiens
Length	507 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (225)

Diseases linked to this target (Open Targets).

bone density · score 0.29
monocyte count · score 0.29
vital capacity · score 0.28
systolic blood pressure · score 0.25
serum alanine aminotransferase measurement · score 0.24
schizophrenia · score 0.23
hemoglobin A1 measurement · score 0.21
autism spectrum disorder · score 0.20
smoking status measurement · score 0.20
sex hormone-binding globulin measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZVM7-F1	alphafold	PREDICTED	69.82	—

Amino-acid sequence (507 residues)

MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA IRALKKRLNG NRNYREVMLA LTVLETCVKN CGHRFHILVA NRDFIDSVLV KIISPKNNPP TIVQDKVLAL IQAWADAFRS SPDLTGVVHI YEELKRKGVE FPMADLDALS PIHTPQRSVP EVDPAATMPR SQSQQRTSAG SYSSPPPAPY SAPQAPALSV TGPITANSEQ IARLRSELDV VRGNTKVMSE MLTEMVPGQE DSSDLELLQE LNRTCRAMQQ RIVELISRVS NEEVTEELLH VNDDLNNVFL RYERFERYRS GRSVQNASNG VLNEVTEDNL IDLGPGSPAV VSPMVGNTAP PSSLSSQLAG LDLGTESVSG TLSSLQQCNP RDGFDMFAQT RGNSLAEQRK TVTYEDPQAV GGLASALDNR KQSSEGIPVA QPSVMDDIEV WLRTDLKGDD LEEGVTSEEF DKFLEERAKA AEMVPDLPSP PMEAPAPASN PSGRKKPERS EDALFAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards