Ret finger protein-like 4B (RFPL4B)

About Ret finger protein-like 4B

Ret finger protein-like 4B (RFPL4B) is a protein from Homo sapiens identified by UniProt accession Q6ZWI9, 263 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.

Target properties

Protein name	Ret finger protein-like 4B
UniProt accession	Q6ZWI9
Gene	RFPL4B
Organism	Homo sapiens
Length	263 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (7)

Diseases linked to this target (Open Targets).

drug use measurement · score 0.24
metabolite measurement · score 0.21
genetic disorder · score 0.12
foot fracture · score 0.07
cytotoxicity measurement · score 0.05
response to clozapine · score 0.05
hepatocellular carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZWI9-F1	alphafold	PREDICTED	83.45	—

Amino-acid sequence (263 residues)

MAKRLQAELS CPVCLDFFSC SISLSCTHVF CFDCIQRYIL ENHDFRAMCP LCRDVVKVPA LEEWQVSVLT LMTKQHNSRL EQSLHVREEL RHFREDVTLD AATASSLLVF SNDLRSAQCK KIHHDLTKDP RLACVLGTPC FSSGQHYWEV EVGEVKSWSL GVCKEPADRK SNDLFPEHGF WISMKAGAIH ANTHLERIPA SPRLRRVGIF LDADLEEIQF FDVDNNVLIY THDGFFSLEL LCPFFCLELL GEGESGNVLT ICP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards