About Ubiquitin carboxyl-terminal hydrolase 49
Ubiquitin carboxyl-terminal hydrolase 49 (USP49) is a protein
from Homo sapiens identified by UniProt accession
Q70CQ1, 688 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 49 |
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| UniProt accession | Q70CQ1 |
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| Gene | USP49 |
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| Organism | Homo sapiens |
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| Length | 688 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (72)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.43
- mean corpuscular hemoglobin concentration · score 0.38
- appendicular lean mass · score 0.38
- erythrocyte count · score 0.38
- mean reticulocyte volume · score 0.38
- mean corpuscular hemoglobin · score 0.36
- BMI-adjusted hip circumference · score 0.34
- monocyte percentage of leukocytes · score 0.31
- body height · score 0.28
- platelet component distribution width · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q70CQ1-F1 | alphafold | PREDICTED | 71.09 | — |
Amino-acid sequence (688 residues)
MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESVWACLK CSHVACGRYI EDHALKHFEE TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDTP VRRGRTLRSM ASGEDVVLPQ RAPQGQPQML TALWYRRQRL LARTLRLWFE KSSRGQAKLE QRRQEEALER KKEEARRRRR EVKRRLLEEL ASTPPRKSAR LLLHTPRDAG PAASRPAALP TSRRVPAATL KLRRQPAMAP GVTGLRNLGN TCYMNSILQV LSHLQKFREC FLNLDPSKTE HLFPKATNGK TQLSGKPTNS SATELSLRND RAEACEREGF CWNGRASISR SLELIQNKEP SSKHISLCRE LHTLFRVMWS GKWALVSPFA MLHSVWSLIP AFRGYDQQDA QEFLCELLHK VQQELESEGT TRRILIPFSQ RKLTKQVLKV VNTIFHGQLL SQVTCISCNY KSNTIEPFWD LSLEFPERYH CIEKGFVPLN QTECLLTEML AKFTETEALE GRIYACDQCN SKRRKSNPKP LVLSEARKQL MIYRLPQVLR LHLKRFRWSG RNHREKIGVH VVFDQVLTME PYCCRDMLSS LDKETFAYDL SAVVMHHGKG FGSGHYTAYC YNTEGGFWVH CNDSKLNVCS VEEVCKTQAY ILFYTQRTVQ GNARISETHL QAQVQSSNND EGRPQTFS
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