About Ubiquitin carboxyl-terminal hydrolase 30
Ubiquitin carboxyl-terminal hydrolase 30 (USP30) is a protein
from Homo sapiens identified by UniProt accession
Q70CQ3, 517 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 30 |
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| UniProt accession | Q70CQ3 |
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| Gene | USP30 |
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| Organism | Homo sapiens |
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| Length | 517 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (81)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- platelet count · score 0.33
- mitochondrial DNA measurement · score 0.29
- platelet-to-lymphocyte ratio · score 0.23
- low grade glioma · score 0.23
- platelet component distribution width · score 0.23
- acute myeloid leukemia · score 0.08
- breast cancer · score 0.08
- deafness · score 0.06
- oral squamous cell carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q70CQ3-F1 | alphafold | PREDICTED | 76.78 | — |
Amino-acid sequence (517 residues)
MLSSRAEAAM TAADRAIQRF LRTGAAVRYK VMKNWGVIGG IAAALAAGIY VIWGPITERK KRRKGLVPGL VNLGNTCFMN SLLQGLSACP AFIRWLEEFT SQYSRDQKEP PSHQYLSLTL LHLLKALSCQ EVTDDEVLDA SCLLDVLRMY RWQISSFEEQ DAHELFHVIT SSLEDERDRQ PRVTHLFDVH SLEQQSEITP KQITCRTRGS PHPTSNHWKS QHPFHGRLTS NMVCKHCEHQ SPVRFDTFDS LSLSIPAATW GHPLTLDHCL HHFISSESVR DVVCDNCTKI EAKGTLNGEK VEHQRTTFVK QLKLGKLPQC LCIHLQRLSW SSHGTPLKRH EHVQFNEFLM MDIYKYHLLG HKPSQHNPKL NKNPGPTLEL QDGPGAPTPV LNQPGAPKTQ IFMNGACSPS LLPTLSAPMP FPLPVVPDYS SSTYLFRLMA VVVHHGDMHS GHFVTYRRSP PSARNPLSTS NQWLWVSDDT VRKASLQEVL SSSAYLLFYE RVLSRMQHQS QECKSEE
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