About Ras-associated and pleckstrin homology domains-containing protein 1
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) is a protein
from Homo sapiens identified by UniProt accession
Q70E73, 1250 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Ras-associated and pleckstrin homology domains-containing protein 1 |
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| UniProt accession | Q70E73 |
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| Gene | RAPH1 |
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| Organism | Homo sapiens |
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| Length | 1250 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (174)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- white matter microstructure measurement · score 0.38
- apolipoprotein B measurement · score 0.19
- platelet crit · score 0.17
- butyrylcholinesterase measurement · score 0.17
- urinary albumin to creatinine ratio · score 0.13
- osteoarthritis · score 0.12
- lymphocyte count · score 0.12
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q70E73-F1 | alphafold | PREDICTED | 56.30 | — |
Amino-acid sequence (1250 residues)
MEQLSDEEID HGAEEDSDKE DQDLDKMFGA WLGELDKLTQ SLDSDKPMEP VKRSPLRQET NMANFSYRFS IYNLNEALNQ GETVDLDALM ADLCSIEQEL SSIGSGNSKR QITETKATQK LPVSRHTLKH GTLKGLSSSS NRIAKPSHAS YSLDDVTAQL EQASLSMDEA AQQSVLEDTK PLVTNQHRRT ASAGTVSDAE VHSISNSSHS SITSAASSMD SLDIDKVTRP QELDLTHQGQ PITEEEQAAK LKAEKIRVAL EKIKEAQVKK LVIRVHMSDD SSKTMMVDER QTVRQVLDNL MDKSHCGYSL DWSLVETVSE LQMERIFEDH ENLVENLLNW TRDSQNKLIF MERIEKYALF KNPQNYLLGK KETAEMADRN KEVLLEECFC GSSVTVPEIE GVLWLKDDGK KSWKKRYFLL RASGIYYVPK GKAKVSRDLV CFLQLDHVNV YYGQDYRNKY KAPTDYCLVL KHPQIQKKSQ YIKYLCCDDV RTLHQWVNGI RIAKYGKQLY MNYQEALKRT ESAYDWTSLS SSSIKSGSSS SSIPESQSNH SNQSDSGVSD TQPAGHVRSQ SIVSSVFSEA WKRGTQLEES SKARMESMNR PYTSLVPPLS PQPKIVTPYT ASQPSPPLPP PPPPPPPPPP PPPPPPPPLP SQSAPSAGSA APMFVKYSTI TRLQNASQHS GALFKPPTPP VMQSQSVKPQ ILVPPNGVVP PPPPPPPPPT PGSAMAQLKP APCAPSLPQF SAPPPPLKIH QVQHITQVAP PTPPPPPPIP APLPPQAPPK PLVTIPAPTS TKTVAPVVTQ AAPPTPTPPV PPAKKQPAFP ASYIPPSPPT PPVPVPPPTL PKQQSFCAKP PPSPLSPVPS VVKQIASQFP PPPTPPAMES QPLKPVPANV APQSPPAVKA KPKWQPSSIP VPSPDFPPPP PESSLVFPPP PPSPVPAPPP PPPPTASPTP DKSGSPGKKT SKTSSPGGKK PPPTPQRNSS IKSSSGAEHP EPKRPSVDSL VSKFTPPAES GSPSKETLPP PAAPPKPGKL NLSGVNLPGV LQQGCVSAKA PVLSGRGKDS VVEFPSPPSD SDFPPPPPET ELPLPPIEIP AVFSGNTSPK VAVVNPQPQQ WSKMSVKKAP PPTRPKRNDS TRLTQAEISE QPTMATVVPQ VPTSPKSSLS VQPGFLADLN RTLQRKSITR HGSLSSRMSR AEPTATMDDM ALPPPPPELL SDQQKAGYGG SHISGYATLR RGPPPAPPKR DQNTKLSRDW
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