About Ubiquitin carboxyl-terminal hydrolase 54
Ubiquitin carboxyl-terminal hydrolase 54 (USP54) is a protein
from Homo sapiens identified by UniProt accession
Q70EL1, 1684 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 54 |
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| UniProt accession | Q70EL1 |
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| Gene | USP54 |
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| Organism | Homo sapiens |
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| Length | 1684 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- visceral adipose tissue measurement · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- eosinophil count · score 0.04
- aplasia cutis congenita-intestinal lymphangiectasia syndrome · score 0.04
- Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
- Rh deficiency syndrome · score 0.04
- IRIDA syndrome · score 0.04
- hemoglobin D disease · score 0.04
- megaloblastic anemia, folate-responsive · score 0.04
- sideroblastic anemia 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q70EL1-F1 | alphafold | PREDICTED | 48.29 | — |
Amino-acid sequence (1684 residues)
MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV LWHLDIFRRS FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR SALAKTFQDE QRFQLGIMDD AAECFENLLM RIHFHIADET KEDICTAQHC ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ MVHYISTTSL CNQAICMLER REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM NAPQIITIGL VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA DPQGTPVSTQ DLPPQAEFQS YSRTCYDSED SGREPSISSD TRTDSSTESY PYKHSHHESV VSHFSSDSQG TVIYNVENDS MSQSSRDTGH LTDSECNQKH TSKKGSLIER KRSSGRVRRK GDEPQASGYH SEGETLKEKQ APRNASKPSS STNRLRDFKE TVSNMIHNRP SLASQTNVGS HCRGRGGDQP DKKPPRTLPL HSRDWEIEST SSESKSSSSS KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG PSPQYKRWGP ARPGSHLLEQ HPRLIQRMES GYESSERNSS SPVSLDAALP ESSNVYRDPS AKRSAGLVPS WRHIPKSHSS SILEVDSTAS MGGWTKSQPF SGEEISSKSE LDELQEEVAR RAQEQELRRK REKELEAAKG FNPHPSRFMD LDELQNQGRS DGFERSLQEA ESVFEESLHL EQKGDCAAAL ALCNEAISKL RLALHGASCS THSRALVDKK LQISIRKARS LQDRMQQQQS PQQPSQPSAC LPTQAGTLSQ PTSEQPIPLQ VLLSQEAQLE SGMDTEFGAS SFFHSPASCH ESHSSLSPES SAPQHSSPSR SALKLLTSVE VDNIEPSAFH RQGLPKAPGW TEKNSHHSWE PLDAPEGKLQ GSRCDNSSCS KLPPQEGRGI AQEQLFQEKK DPANPSPVMP GIATSERGDE HSLGCSPSNS SAQPSLPLYR TCHPIMPVAS SFVLHCPDPV QKTNQCLQGQ SLKTSLTLKV DRGSEETYRP EFPSTKGLVR SLAEQFQRMQ GVSMRDSTGF KDRSLSGSLR KNSSPSDSKP PFSQGQEKGH WPWAKQQSSL EGGDRPLSWE ESTEHSSLAL NSGLPNGETS SGGQPRLAEP DIYQEKLSQV RDVRSKDLGS STDLGTSLPL DSWVNITRFC DSQLKHGAPR PGMKSSPHDS HTCVTYPERN HILLHPHWNQ DTEQETSELE SLYQASLQAS QAGCSGWGQQ DTAWHPLSQT GSADGMGRRL HSAHDPGLSK TSTAEMEHGL HEARTVRTSQ ATPCRGLSRE CGEDEQYSAE NLRRISRSLS GTVVSEREEA PVSSHSFDSS NVRKPLETGH RCSSSSSLPV IHDPSVFLLG PQLYLPQPQF LSPDVLMPTM AGEPNRLPGT SRSVQQFLAM CDRGETSQGA KYTGRTLNYQ SLPHRSRTDN SWAPWSETNQ HIGTRFLTTP GCNPQLTYTA TLPERSKGLQ VPHTQSWSDL FHSPSHPPIV HPVYPPSSSL HVPLRSAWNS DPVPGSRTPG PRRVDMPPDD DWRQSSYASH SGHRRTVGEG FLFVLSDAPR REQIRARVLQ HSQW
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