About Cyclic AMP-responsive element-binding protein 3-like protein 2
Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2) is a protein
from Homo sapiens identified by UniProt accession
Q70SY1, 520 residues long.
MolForge cross-references it against 0 known binders and
207 disease associations.
Target properties
| Protein name | Cyclic AMP-responsive element-binding protein 3-like protein 2 |
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| UniProt accession | Q70SY1 |
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| Gene | CREB3L2 |
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| Organism | Homo sapiens |
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| Length | 520 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (207)
Diseases linked to this target (Open Targets).
- body height · score 0.45
- BMI-adjusted waist circumference · score 0.43
- alkaline phosphatase measurement · score 0.40
- monocyte count · score 0.40
- sitting height measurement · score 0.37
- leiomyosarcoma · score 0.37
- myxofibrosarcoma · score 0.37
- lipoma · score 0.37
- malignant peripheral nerve sheath tumor · score 0.37
- synovial sarcoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q70SY1-F1 | alphafold | PREDICTED | 55.52 | — |
Amino-acid sequence (520 residues)
MEVLESGEQG VLQWDRKLSE LSEPGDGEAL MYHTHFSELL DEFSQNVLGQ LLNDPFLSEK SVSMEVEPSP TSPAPLIQAE HSYSLCEEPR AQSPFTHITT SDSFNDDEVE SEKWYLSTDF PSTSIKTEPV TDEPPPGLVP SVTLTITAIS TPLEKEEPPL EMNTGVDSSC QTIIPKIKLE PHEVDQFLNF SPKEAPVDHL HLPPTPPSSH GSDSEGSLSP NPRLHPFSLP QTHSPSRAAP RAPSALSSSP LLTAPHKLQG SGPLVLTEEE KRTLIAEGYP IPTKLPLSKS EEKALKKIRR KIKNKISAQE SRRKKKEYMD SLEKKVESCS TENLELRKKV EVLENTNRTL LQQLQKLQTL VMGKVSRTCK LAGTQTGTCL MVVVLCFAVA FGSFFQGYGP YPSATKMALP SQHSLQEPYT ASVVRSRNLL IYEEHSPPEE SSSPGSAGEL GGWDRGSSLL RVSGLESRPD VDLPHFIISN ETSLEKSVLL ELQQHLVSAK LEGNETLKVV ELDRRVNTTF
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