5-hydroxytryptamine receptor 3D (HTR3D)

About 5-hydroxytryptamine receptor 3D

5-hydroxytryptamine receptor 3D (HTR3D) is a protein from Homo sapiens identified by UniProt accession Q70Z44, 454 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 3D
UniProt accession	Q70Z44
Gene	HTR3D
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.59
post operative nausea and vomiting · score 0.57
irritable bowel syndrome · score 0.54
schizoaffective disorder · score 0.50
type 2 diabetes mellitus · score 0.47
Nausea and vomiting · score 0.46
psychosis · score 0.46
Chemotherapy-induced nausea and vomiting · score 0.44
cancer · score 0.44
Vomiting · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q70Z44-F1	alphafold	PREDICTED	63.38	—

Amino-acid sequence (454 residues)

MQKHSPGPPA LALLSQSLLT TGNGDTLIIN CPGFGQHRVD PAAFQAVFDR KAIGPVTNYS VATHVNISFT LSAIWNCYSR IHTFNCHHAR PWHNQFVQWN PDECGGIKKS GMATENLWLS DVFIEESVDQ TPAGLMASMS IVKATSNTIS QCGWSASANW TPSISPSMDR ARAWRRMSRS FQIHHRTSFR TRREWVLLGI QKRTIKVTVA TNQYEQAIFH VAIRRRCRPS PYVVNFLVPS GILIAIDALS FYLPLESGNC APFKMTVLLG YSVFLLMMND LLPATSTSSH ASLVAPLALM QTPLPAGVYF ALCLSLMVGS LLETIFITHL LHVATTQPLP LPRWLHSLLL HCTGQGRCCP TAPQKGNKGP GLTPTHLPGV KEPEVSAGQM PGPGEAELTG GSEWTRAQRE HEAQKQHSVE LWVQFSHAMD ALLFRLYLLF MASSIITVIC LWNT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards