About Centromere protein U
Centromere protein U (CENPU) is a protein
from Homo sapiens identified by UniProt accession
Q71F23, 418 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Centromere protein U |
|---|
| UniProt accession | Q71F23 |
|---|
| Gene | CENPU |
|---|
| Organism | Homo sapiens |
|---|
| Length | 418 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (103)
Diseases linked to this target (Open Targets).
- mucocutaneous lymph node syndrome · score 0.30
- caspase-3 measurement · score 0.19
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.10
- type 2 diabetes mellitus · score 0.09
- adolescent idiopathic scoliosis · score 0.09
- urinary bladder carcinoma · score 0.08
- Sleep Disorder · score 0.08
- papilloma · score 0.07
- non-small cell lung carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q71F23-F1 | alphafold | PREDICTED | 65.30 | — |
Amino-acid sequence (418 residues)
MAPRGRRRPR PHRSEGARRS KNTLERTHSM KDKAGQKCKP IDVFDFPDNS DVSSIGRLGE NEKDEETYET FDPPLHSTAI YADEEEFSKH CGLSLSSTPP GKEAKRSSDT SGNEASEIES VKISAKKPGR KLRPISDDSE SIEESDTRRK VKSAEKISTQ RHEVIRTTAS SELSEKPAES VTSKKTGPLS AQPSVEKENL AIESQSKTQK KGKISHDKRK KSRSKAIGSD TSDIVHIWCP EGMKTSDIKE LNIVLPEFEK THLEHQQRIE SKVCKAAIAT FYVNVKEQFI KMLKESQMLT NLKRKNAKMI SDIEKKRQRM IEVQDELLRL EPQLKQLQTK YDELKERKSS LRNAAYFLSN LKQLYQDYSD VQAQEPNVKE TYDSSSLPAL LFKARTLLGA ESHLRNINHQ LEKLLDQG
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