Small integral membrane protein 5 (SMIM5)

About Small integral membrane protein 5

Small integral membrane protein 5 (SMIM5) is a protein from Homo sapiens identified by UniProt accession Q71RC9, 77 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Small integral membrane protein 5
UniProt accession	Q71RC9
Gene	SMIM5
Organism	Homo sapiens
Length	77 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

rotator cuff tear · score 0.07
appendicular lean mass · score 0.06
hemoglobin measurement · score 0.05
hematocrit · score 0.04
esophageal squamous cell carcinoma · score 0.03
clear cell renal carcinoma · score 0.03
Tetralogy of Fallot · score 0.02
colorectal cancer · score 0.01
Leishmaniasis · score 0.01
papillary renal cell carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q71RC9-F1	alphafold	PREDICTED	77.32	—

Amino-acid sequence (77 residues)

MAATDFVQEM RAVGERLLLK LQRLPQAEPV EIVAFSVIIL FTATVLLLLL IACSCCCTHC CCPERRGRKV QVQPTPP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards