Transmembrane and ubiquitin-like domain-containing…

About Transmembrane and ubiquitin-like domain-containing protein 2

Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2) is a protein from Homo sapiens identified by UniProt accession Q71RG4, 321 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Transmembrane and ubiquitin-like domain-containing protein 2
UniProt accession	Q71RG4
Gene	TMUB2
Organism	Homo sapiens
Length	321 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.13
body fat distribution · score 0.11
sex hormone-binding globulin measurement · score 0.10
body weight · score 0.09
body mass index · score 0.09
calcium measurement · score 0.09
HbA1c measurement · score 0.08
appendicular lean mass · score 0.08
hematocrit · score 0.07
visceral adipose tissue measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q71RG4-F1	alphafold	PREDICTED	62.07	—

Amino-acid sequence (321 residues)

MISRHLQNNL MSVDPASSQA MELSDVTLIE GVGNEVMVVA GVVVLILALV LAWLSTYVAD SGSNQLLGAI VSAGDTSVLH LGHVDHLVAG QGNPEPTELP HPSEGNDEKA EEAGEGRGDS TGEAGAGGGV EPSLEHLLDI QGLPKRQAGA GSSSPEAPLR SEDSTCLPPS PGLITVRLKF LNDTEELAVA RPEDTVGALK SKYFPGQESQ MKLIYQGRLL QDPARTLRSL NITDNCVIHC HRSPPGSAVP GPSASLAPSA TEPPSLGVNV GSLMVPVFVV LLGVVWYFRI NYRQFFTAPA TVSLVGVTVF FSFLVFGMYG R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)