About Ceramide synthase
Ceramide synthase (TLCD3B) is a protein
from Homo sapiens identified by UniProt accession
Q71RH2, 274 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Ceramide synthase |
|---|
| UniProt accession | Q71RH2 |
|---|
| Gene | TLCD3B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 274 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (110)
Diseases linked to this target (Open Targets).
- Cone rod dystrophy · score 0.37
- appendicular lean mass · score 0.12
- lean body mass · score 0.11
- eosinophil count · score 0.11
- fat body mass · score 0.10
- body height · score 0.10
- neutrophil percentage of granulocytes · score 0.09
- eosinophil percentage of leukocytes · score 0.09
- monocyte count · score 0.09
- eosinophil percentage of granulocytes · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q71RH2-F1 | alphafold | PREDICTED | 89.24 | — |
Amino-acid sequence (274 residues)
MLTPMVAGGV VFPGLFLLSK NTLQRLPQLR WEEADAVIVS ARLVSSVQAI MASTAGYIVS TSCKHIIDDQ HWLSSAYTQF AVPYFIYDIY AMFLCHWHKH QVKGHGGDDG AARAPGSTWA IARGYLHKEF LMVLHHAAMV LVCFPLSVVW RQGKGDFFLG CMLMAEVSTP FVCLGKILIQ YKQQHTLLHK VNGALMLLSF LCCRVLLFPY LYWAYGRHAG LPLLAVPLAI PAHVNLGAAL LLAPQLYWFF LICRGACRLF WPRSRPPPAC QAQD
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