About Sodium/potassium/calcium exchanger 5
Sodium/potassium/calcium exchanger 5 (SLC24A5) is a protein
from Homo sapiens identified by UniProt accession
Q71RS6, 500 residues long.
MolForge cross-references it against 0 known binders and
250 disease associations.
Target properties
| Protein name | Sodium/potassium/calcium exchanger 5 |
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| UniProt accession | Q71RS6 |
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| Gene | SLC24A5 |
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| Organism | Homo sapiens |
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| Length | 500 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (250)
Diseases linked to this target (Open Targets).
- oculocutaneous albinism type 6 · score 0.68
- oculocutaneous albinism · score 0.65
- skin pigmentation measurement · score 0.49
- hair colour measurement · score 0.47
- eye colour measurement · score 0.46
- genetic disorder · score 0.41
- skin pigmentation · score 0.40
- oculocutaneous albinism type 7 · score 0.38
- neurodegenerative disease · score 0.34
- nose morphology measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q71RS6-F1 | alphafold | PREDICTED | 76.40 | — |
Amino-acid sequence (500 residues)
MQTKGGQTWA RRALLLGILW ATAHLPLSGT SLPQRLPRAT GNSTQCVISP SSEFPEGFFT RQERRDGGII IYFLIIVYMF MAISIVCDEY FLPSLEIISE SLGLSQDVAG TTFMAAGSSA PELVTAFLGV FITKGDIGIS TILGSAIYNL LGICAACGLL SNTVSTLSCW PLFRDCAAYT ISAAAVLGII YDNQVYWYEG ALLLLIYGLY VLVLCFDIKI NQYIIKKCSP CCACLAKAME RSEQQPLMGW EDEGQPFIRR QSRTDSGIFY EDSGYSQLSI SLHGLSQVSE DPPSVFNMPE ADLKRIFWVL SLPIITLLFL TTPDCRKKFW KNYFVITFFM SAIWISAFTY ILVWMVTITG ETLEIPDTVM GLTLLAAGTS IPDTIASVLV ARKGKGDMAM SNIVGSNVFD MLCLGIPWFI KTAFINGSAP AEVNSRGLTY ITISLNISII FLFLAVHFNG WKLDRKLGIV CLLSYLGLAT LSVLYELGII GNNKIRGCGG
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