About Mediator of RNA polymerase II transcription subunit 25
Mediator of RNA polymerase II transcription subunit 25 (MED25) is a protein
from Homo sapiens identified by UniProt accession
Q71SY5, 747 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 25 |
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| UniProt accession | Q71SY5 |
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| Gene | MED25 |
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| Organism | Homo sapiens |
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| Length | 747 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- congenital cataract-microcephaly-nevus flammeus simplex-severe intellectual disability syndrome · score 0.73
- neurodegenerative disease · score 0.54
- genetic disorder · score 0.47
- Charcot-Marie-Tooth disease type 2B2 · score 0.46
- Tip-toe gait · score 0.45
- Charcot-Marie-Tooth disease type 2 · score 0.42
- autosomal recessive non-syndromic intellectual disability · score 0.37
- syndromic intellectual disability · score 0.37
- total blood protein measurement · score 0.37
- Charcot-Marie-Tooth disease · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q71SY5-F1 | alphafold | PREDICTED | 62.51 | — |
Amino-acid sequence (747 residues)
MVPGSEGPAR AGSVVADVVF VIEGTANLGP YFEGLRKHYL LPAIEYFNGG PPAETDFGGD YGGTQYSLVV FNTVDCAPES YVQCHAPTSS AYEFVTWLDG IKFMGGGGES CSLIAEGLST ALQLFDDFKK MREQIGQTHR VCLLICNSPP YLLPAVESTT YSGCTTENLV QQIGERGIHF SIVSPRKLPA LRLLFEKAAP PALLEPLQPP TDVSQDPRHM VLVRGLVLPV GGGSAPGPLQ SKQPVPLPPA APSGATLSAA PQQPLPPVPP QYQVPGNLSA AQVAAQNAVE AAKNQKAGLG PRFSPITPLQ QAAPGVGPPF SQAPAPQLPP GPPGAPKPPP ASQPSLVSTV APGSGLAPTA QPGAPSMAGT VAPGGVSGPS PAQLGAPALG GQQSVSNKLL AWSGVLEWQE KPKPASVDAN TKLTRSLPCQ VYVNHGENLK TEQWPQKLIM QLIPQQLLTT LGPLFRNSRM VQFHFTNKDL ESLKGLYRIM GNGFAGCVHF PHTAPCEVRV LMLLYSSKKK IFMGLIPYDQ SGFVNGIRQV ITNHKQVQQQ KLEQQQRGMG GQQAPPGLGP ILEDQARPSQ NLLQLRPPQP QPQGTVGASG ATGQPQPQGT AQPPPGAPQG PPGAASGPPP PGPILRPQNP GANPQLRSLL LNPPPPQTGV PPPQASLHHL QPPGAPALLP PPHQGLGQPQ LGPPLLHPPP AQSWPAQLPP RAPLPGQMLL SGGPRGPVPQ PGLQPSVMED DILMDLI
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