Tubulin alpha-1A chain (TUBA1A)

About Tubulin alpha-1A chain

Tubulin alpha-1A chain (TUBA1A) is a protein from Homo sapiens identified by UniProt accession Q71U36, 451 residues long. MolForge cross-references it against 0 known binders and 263 disease associations.

Target properties

Protein name	Tubulin alpha-1A chain
UniProt accession	Q71U36
Gene	TUBA1A
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (263)

Diseases linked to this target (Open Targets).

lissencephaly due to TUBA1A mutation · score 0.82
tubulinopathy · score 0.66
tubulinopathy-associated dysgyria · score 0.61
lissencephaly type 3 · score 0.61
Lissencephaly · score 0.58
genetic disorder · score 0.54
congenital fibrosis of extraocular muscles · score 0.53
neurodegenerative disease · score 0.53
Intellectual disability · score 0.51
viral disease · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q71U36-F1	alphafold	PREDICTED	91.12	—

Amino-acid sequence (451 residues)

MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL IGQIVSSITA SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE AREDMAALEK DYEEVGVDSV EGEGEEEGEE Y

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards