Histone H2A.V (H2AZ2)

About Histone H2A.V

Histone H2A.V (H2AZ2) is a protein from Homo sapiens identified by UniProt accession Q71UI9, 128 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Histone H2A.V
UniProt accession	Q71UI9
Gene	H2AZ2
Organism	Homo sapiens
Length	128 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

melanoma · score 0.38
cancer · score 0.37
breast carcinoma · score 0.37
platelet count · score 0.34
mean corpuscular volume · score 0.33
mean platelet volume · score 0.32
erythrocyte count · score 0.32
mean corpuscular hemoglobin · score 0.32
mean corpuscular hemoglobin concentration · score 0.31
eosinophil count · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q71UI9-F1	alphafold	PREDICTED	89.75	—

Amino-acid sequence (128 residues)

MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG KKGQQKTA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards