E3 ubiquitin-protein ligase Hakai (CBLL1)

About E3 ubiquitin-protein ligase Hakai

E3 ubiquitin-protein ligase Hakai (CBLL1) is a protein from Homo sapiens identified by UniProt accession Q75N03, 491 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase Hakai
UniProt accession	Q75N03
Gene	CBLL1
Organism	Homo sapiens
Length	491 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
listeriosis · score 0.46
lysosomal storage disease · score 0.37
lymphocyte count · score 0.28
endometrial cancer · score 0.23
hepatocellular carcinoma · score 0.20
clear cell renal carcinoma · score 0.17
gastric adenocarcinoma · score 0.11
neoplasm · score 0.10
non-small cell lung carcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q75N03-F1	alphafold	PREDICTED	56.60	—

Amino-acid sequence (491 residues)

MDHTDNELQG TNSSGSLGGL DVRRRIPIKL ISKQANKAKP APRTQRTINR MPAKAPPGDE EGFDYNEEER YDCKGGELFA NQRRFPGHLF WDFQINILGE KDDTPVHFCD KCGLPIKIYG RMIPCKHVFC YDCAILHEKK GDKMCPGCSD PVQRIEQCTR GSLFMCSIVQ GCKRTYLSQR DLQAHINHRH MRAGKPVTRA SLENVHPPIA PPPTEIPERF IMPPDKHHMS HIPPKQHIMM PPPPLQHVPH EHYNQPHEDI RAPPAELSMA PPPPRSVSQE TFRISTRKHS NLITVPIQDD SNSGAREPPP PAPAPAHHHP EYQGQPVVSH PHHIMPPQQH YAPPPPPPPP ISHPMPHPPQ AAGTPHLVYS QAPPPPMTSA PPPITPPPGH IIAQMPPYMN HPPPGPPPPQ HGGPPVTAPP PHHYNPNSLP QFTEDQGTLS PPFTQPGGMS PGIWPAPRGP PPPPRLQGPP SQTPLPGPHH PDQTRYRPYY Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards