About Kinase non-catalytic C-lobe domain-containing protein 1
Kinase non-catalytic C-lobe domain-containing protein 1 (KNDC1) is a protein
from Homo sapiens identified by UniProt accession
Q76NI1, 1749 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Kinase non-catalytic C-lobe domain-containing protein 1 |
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| UniProt accession | Q76NI1 |
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| Gene | KNDC1 |
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| Organism | Homo sapiens |
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| Length | 1749 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.27
- multisite chronic pain · score 0.21
- neurodegenerative disease · score 0.19
- breast ductal adenocarcinoma · score 0.11
- testosterone measurement · score 0.09
- gastroesophageal reflux disease · score 0.09
- lung carcinoma · score 0.07
- glioblastoma multiforme · score 0.04
- neoplasm · score 0.03
- medulloblastoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q76NI1-F1 | alphafold | PREDICTED | 60.28 | — |
Amino-acid sequence (1749 residues)
MQAMDPAAAD LYEEDGKDLD FYDFEPLPTL PEDEENVSLA DILSLRDRGL SEQEAWAVCL ECSLSMRSVA HAAIFQSLCI TPDTLAFNTS GNVCFMEQLS DDPEGAFVPP EFDVTGNTFE AHIYSLGATL KAALEYVAEP TLEPRLSQDL EALLSRMQAE DPGDRPDLES IIALCEEKLQ LTSSCRVCRS LSAVGRRVLS IESFGALQDV SESSWRERPA PGNAGPRRPP GDPSTDPEVL PTPEGPESET SRGPRASPTK ALLSTPVRNG ESHSREGLAG LVLDAERTLG ELDRDALRRS RLRKVQTFPR LLSDSPEATL CLPLTRGKSQ LPISELFSPD PRKAFLDRKN GLSSFQAQPK CRLWPEQEPE HQLGRVPCAG RSTDRGPGVP GSPGQPETSH PSQGPAEAPA DPRDASGEAQ TPRDDERIPE GARQLESAAA EQWVSLQDLL SQLGRPFREY ELWALCLACL RALQTRPEHP AYLCLDSVLV AEDGAVLFQP PPANGSYDSF FLAPELAEER LVTEKASVYC VAAVLWTAAK FSVPRNHKLA LPRRLKTLLL DMARRSAPER PSAAEAIKVC GSYLLQRGMD SRKILAHLRA SICQVYQEEE TISLQNAFSV VELKPSVAPA PEPSPGFLPV NSDTGLVAVP GPVPGQHPCG EEATQLPAAF TSEATHFKPI VLAQNASVAR DQPALAQEES EERGGQREGE GEEKLSLEAH AGSPSLKTPD GPVPGPGPQG AAPEPLGASV QRDSAQGRPC PPPQAPANQP EGASSAAPGS PVPAPPTKAS ALPVEQGPAE PIPPGVASGG LRPDALGPTT AHHGPRHPPK PPRSKATERP GQEPEGPGAT PAGERDDQSP DSVPERPRPA DRRLCLPCVD ASPLPGRTAC PSLQEATRLI QEEFAFDGYL DNGLEALIMG EYIFALKDLT FATFCGAISE KFCDLYWDEK LLQNLFKVVN GQASPSPSTA EEAGSQLEGS QSPRSPSSKR PSLHRLGKEK PAMARTSSRA PCSPTSVSDV DSDALSRGNF EVGFRPQRSV KAERAQQPEA GEDRRPAGGA SDVEAVTRLA RSKGVGPALS PGPAGFQSCS PGWCSAFYEA DCFGADVHNY VKDLGRQQAD GALPDAQSPE LEQQLMMEKR NYRKTLKFYQ KLLQKEKRNK GSDVKTMLSK LKGQLEEMKS RVQFLSLVKK YLQVMYAERW GLEPCTLPVI VNIAAAPCDT LDFSPLDESS SLIFYNVNKH PGGRQKARIL QAGTPLGLMA YLYSSDAFLE GYVQQFLYTF RYFCTPHDFL HFLLDRINST LTRAHQDPTS TFTKIYRRSL CVLQAWVEDC YAVDFPRNSG LLGKLEDFIS SKILPLDGSA KHLLGLLEVG MDRRAEGNPR GTDLENPREA EEDARPFNAL CKRLSEDGIS RKSFPWRLPR GNGLVLPPHK ERPYTIAAAL PKPCFLEDFY GPCAKTSEKG PYFLTEYSTH QLFSQLTLLQ QELFQKCHPV HFLNSRALGV MDKSTAIPKA SSSESLSAKT CSLFLPNYVQ DKYLLQLLRN ADDVSTWVAA EIVTSHTSKL QVNLLSKFLL IAKSCYEQRN FATAMQILSG LEHLAVRQSP AWRILPAKIA EVMEELKAVE VFLKSDSLCL MEGRRFRAQP TLPSAHLLAM HIQQLETGGF TMTNGAHRWS KLRNIAKVVS QVHAFQENPY TFSPDPKLQS YLKQRIARFS GADISTLAAD SRANFHQVSS EKHSRKIQDK LRRMKATFQ
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