About Butyrophilin subfamily 2 member A1
Butyrophilin subfamily 2 member A1 (BTN2A1) is a protein
from Homo sapiens identified by UniProt accession
Q7KYR7, 527 residues long.
MolForge cross-references it against 0 known binders and
176 disease associations.
Target properties
| Protein name | Butyrophilin subfamily 2 member A1 |
|---|
| UniProt accession | Q7KYR7 |
|---|
| Gene | BTN2A1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 527 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (176)
Diseases linked to this target (Open Targets).
- ankylosing spondylitis · score 0.21
- inflammatory spondylopathy · score 0.13
- cutaneous melanoma · score 0.12
- Iridocyclitis · score 0.12
- mathematical ability · score 0.11
- cognitive function measurement · score 0.10
- gastroesophageal reflux disease · score 0.10
- intelligence · score 0.10
- depressive symptom measurement · score 0.09
- Crohn's disease · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7KYR7-F1 | alphafold | PREDICTED | 84.84 | — |
Amino-acid sequence (527 residues)
MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR CHLSPEKNAE DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS KDISRGSVAL VIHNITAQEN GTYRCYFQEG RSYDEAILHL VVAGLGSKPL ISMRGHEDGG IRLECISRGW YPKPLTVWRD PYGGVAPALK EVSMPDADGL FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF MPSVSPCAVA LPIIVVILMI PIAVCIYWIN KLQKEKKILS GEKEFERETR EIALKELEKE RVQKEEELQV KEKLQEELRW RRTFLHAVDV VLDPDTAHPD LFLSEDRRSV RRCPFRHLGE SVPDNPERFD SQPCVLGRES FASGKHYWEV EVENVIEWTV GVCRDSVERK GEVLLIPQNG FWTLEMHKGQ YRAVSSPDRI LPLKESLCRV GVFLDYEAGD VSFYNMRDRS HIYTCPRSAF SVPVRPFFRL GCEDSPIFIC PALTGANGVT VPEEGLTLHR VGTHQSL
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