Protein RUFY3 (RUFY3)

About Protein RUFY3

Protein RUFY3 (RUFY3) is a protein from Homo sapiens identified by UniProt accession Q7L099, 469 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Protein RUFY3
UniProt accession	Q7L099
Gene	RUFY3
Organism	Homo sapiens
Length	469 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

diabetes mellitus · score 0.19
type 2 diabetes mellitus · score 0.12
serum metabolite measurement · score 0.09
mean corpuscular volume · score 0.08
subarachnoid hemorrhage · score 0.07
Red cell distribution width · score 0.07
mean corpuscular hemoglobin concentration · score 0.07
MALT lymphoma · score 0.07
triglyceride measurement · score 0.06
Meckel's diverticulum · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7L099-F1	alphafold	PREDICTED	81.77	—

Amino-acid sequence (469 residues)

MSALTPPTDM PTPTTDKITQ AAMETIYLCK FRVSMDGEWL CLRELDDISL TPDPEPTHED PNYLMANERM NLMNMAKLSI KGLIESALNL GRTLDSDYAP LQQFFVVMEH CLKHGLKAKK TFLGQNKSFW GPLELVEKLV PEAAEITASV KDLPGLKTPV GRGRAWLRLA LMQKKLSEYM KALINKKELL SEFYEPNALM MEEEGAIIAG LLVGLNVIDA NFCMKGEDLD SQVGVIDFSM YLKDGNSSKG TEGDGQITAI LDQKNYVEEL NRHLNATVNN LQAKVDALEK SNTKLTEELA VANNRIITLQ EEMERVKEES SYILESNRKG PKQDRTAEGQ ALSEARKHLK EETQLRLDVE KELEMQISMR QEMELAMKML EKDVCEKQDA LVSLRQQLDD LRALKHELAF KLQSSDLGVK QKSELNSRLE EKTNQMAATI KQLEQSEKDL VKQAKTLNSA ANKLIPKHH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards