BTB/POZ domain-containing protein KCTD9 (KCTD9)

About BTB/POZ domain-containing protein KCTD9

BTB/POZ domain-containing protein KCTD9 (KCTD9) is a protein from Homo sapiens identified by UniProt accession Q7L273, 389 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.

Target properties

Protein name	BTB/POZ domain-containing protein KCTD9
UniProt accession	Q7L273
Gene	KCTD9
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (146)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.31
body height · score 0.31
reticulocyte count · score 0.30
Immature Reticulocyte Fraction Measurement · score 0.27
heel bone mineral density · score 0.26
Red cell distribution width · score 0.26
BMI-adjusted waist-hip ratio · score 0.24
BMI-adjusted waist circumference · score 0.22
triglyceride measurement · score 0.22
waist-hip ratio · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7L273-F1	alphafold	PREDICTED	89.77	—

Amino-acid sequence (389 residues)

MRRVTLFLNG SPKNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI DDIALIRDDD VLFVCEGEPF IDPQTDSKPP EGLLGFHTDW LTLNVGGRYF TTTRSTLVNK EPDSMLAHMF KDKGVWGNKQ DHRGAFLIDR SPEYFEPILN YLRHGQLIVN DGINLLGVLE EARFFGIDSL IEHLEVAIKN SQPPEDHSPI SRKEFVRFLL ATPTKSELRC QGLNFSGADL SRLDLRYINF KMANLSRCNL AHANLCCANL ERADLSGSVL DCANLQGVKM LCSNAEGASL KLCNFEDPSG LKANLEGANL KGVDMEGSQM TGINLRVATL KNAKLKNCNL RGATLAGTDL ENCDLSGCDL QEANLRGSNV KGAIFEEMLT PLHMSQSVR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards