BEN domain-containing protein 5 (BEND5)

About BEN domain-containing protein 5

BEN domain-containing protein 5 (BEND5) is a protein from Homo sapiens identified by UniProt accession Q7L4P6, 421 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	BEN domain-containing protein 5
UniProt accession	Q7L4P6
Gene	BEND5
Organism	Homo sapiens
Length	421 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

body mass index · score 0.25
Impacted tooth · score 0.17
primary ovarian insufficiency · score 0.12
neuroticism measurement · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11
prostate carcinoma · score 0.11
smoking initiation · score 0.11
FEV/FVC ratio · score 0.10
lung adenocarcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7L4P6-F1	alphafold	PREDICTED	73.39	—

Amino-acid sequence (421 residues)

MYAFVRFLED NVCYALPVSC VRDFSPRSRL DFDNQKVYAV YRGPEELGAG PESPPRAPRD WGALLLHKAQ ILALAEDKSD LENSVMQKKI KIPKLSLNHV EEDGEVKDYG EEDLQLRHIK RPEGRKPSEV AHKSIEAVVA RLEKQNGLSL GHSTCPEEVF VEASPGTEDM DSLEDAVVPR ALYEELLRNY QQQQEEMRHL QQELERTRRQ LVQQAKKLKE YGALVSEMKE LRDLNRRLQD VLLLRLGSGP AIDLEKVKSE CLEPEPELRS TFSEEANTSS YYPAPAPVMD KYILDNGKVH LGSGIWVDEE KWHQLQVTQG DSKYTKNLAV MIWGTDVLKN RSVTGVATKK KKDAVPKPPL SPHKLSIVRE CLYDRIAQET VDETEIAQRL SKVNKYICEK IMDINKSCKN EERREAKYNL Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards