Ras-related GTP-binding protein A (RRAGA)

About Ras-related GTP-binding protein A

Ras-related GTP-binding protein A (RRAGA) is a protein from Homo sapiens identified by UniProt accession Q7L523, 313 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Ras-related GTP-binding protein A
UniProt accession	Q7L523
Gene	RRAGA
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

cataract · score 0.37
Cataract · score 0.37
neurodegenerative disease · score 0.33
glioblastoma multiforme · score 0.25
endometrial cancer · score 0.23
head and neck squamous cell carcinoma · score 0.18
esophageal cancer · score 0.15
urinary bladder cancer · score 0.12
platelet count · score 0.10
mean platelet volume · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7L523-F1	alphafold	PREDICTED	92.49	—

Amino-acid sequence (313 residues)

MPNTAMKKKV LLMGKSGSGK TSMRSIIFAN YIARDTRRLG ATIDVEHSHV RFLGNLVLNL WDCGGQDTFM ENYFTSQRDN IFRNVEVLIY VFDVESRELE KDMHYYQSCL EAILQNSPDA KIFCLVHKMD LVQEDQRDLI FKEREEDLRR LSRPLECACF RTSIWDETLY KAWSSIVYQL IPNVQQLEMN LRNFAQIIEA DEVLLFERAT FLVISHYQCK EQRDVHRFEK ISNIIKQFKL SCSKLAASFQ SMEVRNSNFA AFIDIFTSNT YVMVVMSDPS IPSAATLINI RNARKHFEKL ERVDGPKHSL LMR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards