About Docking protein 3
Docking protein 3 (DOK3) is a protein
from Homo sapiens identified by UniProt accession
Q7L591, 496 residues long.
MolForge cross-references it against 0 known binders and
136 disease associations.
Target properties
| Protein name | Docking protein 3 |
|---|
| UniProt accession | Q7L591 |
|---|
| Gene | DOK3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 496 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (136)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- mean corpuscular volume · score 0.22
- inflammatory bowel disease · score 0.16
- heel bone mineral density · score 0.15
- forced expiratory volume · score 0.13
- neoplasm · score 0.09
- lymphocyte percentage of leukocytes · score 0.09
- colitis · score 0.07
- small cell lung carcinoma · score 0.07
- lung cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7L591-F1 | alphafold | PREDICTED | 64.86 | — |
Amino-acid sequence (496 residues)
MTRGARLRSD ARAQLNQLSL DGGTGSGQKG KCEEFPSSLS SVSPGLEAAA LLLAVTMDPL ETPIKDGILY QQHVKFGKKC WRKVWALLYA GGPSGVARLE SWEVRDGGLG AAGDRSAGPG RRGERRVIRL ADCVSVLPAD GESCPRDTGA FLLTTTERSH LLAAQHRQAW MGPICQLAFP GTGEASSGST DAQSPKRGLV PMEENSIYSS WQEVGEFPVV VQRTEAATRC QLKGPALLVL GPDAIQLREA KGTQALYSWP YHFLRKFGSD KGVFSFEAGR RCHSGEGLFA FSTPCAPDLC RAVAGAIARQ RERLPELTRP QPCPLPRATS LPSLDTPGEL REMPPGPEPP TSRKMHLAEP GPQSLPLLLG PEPNDLASGL YASVCKRASG PPGNEHLYEN LCVLEASPTL HGGEPEPHEG PGSRSPTTSP IYHNGQDLSW PGPANDSTLE AQYRRLLELD QVEGTGRPDP QAGFKAKLVT LLSRERRKGP APCDRP
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