About Protein arginine methyltransferase NDUFAF7, mitochondrial
Protein arginine methyltransferase NDUFAF7, mitochondrial (NDUFAF7) is a protein
from Homo sapiens identified by UniProt accession
Q7L592, 441 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Protein arginine methyltransferase NDUFAF7, mitochondrial |
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| UniProt accession | Q7L592 |
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| Gene | NDUFAF7 |
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| Organism | Homo sapiens |
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| Length | 441 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- neutrophil percentage of leukocytes · score 0.25
- neutrophil count · score 0.25
- lymphocyte percentage of leukocytes · score 0.20
- blood pressure · score 0.18
- hypertension · score 0.17
- reticulocyte count · score 0.16
- myeloid white cell count · score 0.12
- Alzheimer disease · score 0.11
- schizophrenia · score 0.07
- leukocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7L592-F1 | alphafold | PREDICTED | 85.49 | — |
Amino-acid sequence (441 residues)
MSVLLRSGLG PLCAVARAAI PFIWRGKYFS SGNEPAENPV TPMLRHLMYK IKSTGPITVA EYMKEVLTNP AKGYYVYRDM LGEKGDFITS PEISQIFGEL LGIWFISEWM ATGKSTAFQL VELGPGRGTL VGDILRVFTQ LGSVLKNCDI SVHLVEVSQK LSEIQALTLT KEKVPLERNA GSPVYMKGVT KSGIPISWYR DLHDVPKGYS FYLAHEFFDV LPVHKFQKTP QGWREVFVDI DPQVSDKLRF VLAPSATPAE AFIQHDETRD HVEVCPDAGV IIEELSQRIA LTGGAALVAD YGHDGTKTDT FRGFCDHKLH DVLIAPGTAD LTADVDFSYL RRMAQGKVAS LGPIKQHTFL KNMGIDVRLK VLLDKSNEPS VRQQLLQGYD MLMNPKKMGE RFNFFALLPH QRLQGGRYQR NARQSKPFAS VVAGFSELAW Q
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