Zinc finger protein 627 (ZNF627)

About Zinc finger protein 627

Zinc finger protein 627 (ZNF627) is a protein from Homo sapiens identified by UniProt accession Q7L945, 461 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Zinc finger protein 627
UniProt accession	Q7L945
Gene	ZNF627
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

Spondyloenchondrodysplasia with immune dysregulation · score 0.57
genetic disorder · score 0.47
blood protein measurement · score 0.29
neurodegenerative disease · score 0.16
3-hydroxypropylmercapturic acid measurement · score 0.10
mean platelet volume · score 0.09
myocardial infarction · score 0.02
colorectal cancer · score 0.01
medulloblastoma · score 0.01
esophageal squamous cell carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7L945-F1	alphafold	PREDICTED	69.05	—

Amino-acid sequence (461 residues)

MDSVAFEDVA VNFTLEEWAL LDPSQKNLYR DVMRETFRNL ASVGKQWEDQ NIEDPFKIPR RNISHIPERL CESKEGGQGE ETFSQIPDGI LNKKTPGVKP CESSVCGEVG MGPSSLNRHI RDHTGREPNE YQEYGKKSYT RNQCGRALSY HRSFPVRERT HPGGKPYDCK ECGETFISLV SIRRHMLTHR GGVPYKCKVC GKAFDYPSLF RIHERSHTGE KPYECKQCGK AFSCSSYIRI HERTHTGDKP YECKQCGKAF SCSKYIRIHE RTHTGEKPYE CKQCGKAFRC ASSVRSHERT HTGEKLFECK ECGKALTCLA SVRRHMIKHT GNGPYKCKVC GKAFDFPSSF RIHERTHTGE KPYDCKQCGK AFSCSSSFRK HERIHTGEKP YKCTKCGKAF SRSSYFRIHE RTHTGEKPYE CKQCGKAFSR STYFRVHEKI HTGEKPYENP NPNASVVPVL S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards