About Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2) is a protein
from Homo sapiens identified by UniProt accession
Q7L985, 606 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 |
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| UniProt accession | Q7L985 |
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| Gene | LINGO2 |
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| Organism | Homo sapiens |
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| Length | 606 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.49
- body mass index · score 0.48
- lean body mass · score 0.46
- body fat percentage · score 0.45
- fat body mass · score 0.43
- high density lipoprotein cholesterol measurement · score 0.43
- physical activity measurement · score 0.42
- smoking behavior · score 0.41
- type 2 diabetes mellitus · score 0.41
- hip bone size · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7L985-F1 | alphafold | PREDICTED | 84.80 | — |
Amino-acid sequence (606 residues)
MLHTAISCWQ PFLGLAVVLI FMGSTIGCPA RCECSAQNKS VSCHRRRLIA IPEGIPIETK ILDLSKNRLK SVNPEEFISY PLLEEIDLSD NIIANVEPGA FNNLFNLRSL RLKGNRLKLV PLGVFTGLSN LTKLDISENK IVILLDYMFQ DLHNLKSLEV GDNDLVYISH RAFSGLLSLE QLTLEKCNLT AVPTEALSHL RSLISLHLKH LNINNMPVYA FKRLFHLKHL EIDYWPLLDM MPANSLYGLN LTSLSVTNTN LSTVPFLAFK HLVYLTHLNL SYNPISTIEA GMFSDLIRLQ ELHIVGAQLR TIEPHSFQGL RFLRVLNVSQ NLLETLEENV FSSPRALEVL SINNNPLACD CRLLWILQRQ PTLQFGGQQP MCAGPDTIRE RSFKDFHSTA LSFYFTCKKP KIREKKLQHL LVDEGQTVQL ECSADGDPQP VISWVTPRRR FITTKSNGRA TVLGDGTLEI RFAQDQDSGM YVCIASNAAG NDTFTASLTV KGFASDRFLY ANRTPMYMTD SNDTISNGTN ANTFSLDLKT ILVSTAMGCF TFLGVVLFCF LLLFVWSRGK GKHKNSIDLE YVPRKNNGAV VEGEVAGPRR FNMKMI
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