About Activity-regulated cytoskeleton-associated protein
Activity-regulated cytoskeleton-associated protein (ARC) is a protein
from Homo sapiens identified by UniProt accession
Q7LC44, 396 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Activity-regulated cytoskeleton-associated protein |
|---|
| UniProt accession | Q7LC44 |
|---|
| Gene | ARC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 396 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (69)
Diseases linked to this target (Open Targets).
- pepsinogen I/II ratio · score 0.29
- self reported educational attainment · score 0.27
- gastric carcinoma · score 0.23
- smoking status measurement · score 0.20
- risk-taking behaviour · score 0.09
- specific language impairment · score 0.08
- Autism · score 0.08
- breast carcinoma · score 0.08
- neoplasm · score 0.08
- metabolite measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7LC44-F1 | alphafold | PREDICTED | 65.07 | — |
Amino-acid sequence (396 residues)
MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE
Explore Activity-regulated cytoskeleton-associated protein with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets