About RAS guanyl-releasing protein 2
RAS guanyl-releasing protein 2 (RASGRP2) is a protein
from Homo sapiens identified by UniProt accession
Q7LDG7, 609 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | RAS guanyl-releasing protein 2 |
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| UniProt accession | Q7LDG7 |
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| Gene | RASGRP2 |
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| Organism | Homo sapiens |
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| Length | 609 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (132)
Diseases linked to this target (Open Targets).
- platelet-type bleeding disorder 18 · score 0.76
- Rare hemorrhagic disorder due to a platelet receptor defect · score 0.67
- lymphocyte count · score 0.51
- Abnormal platelet aggregation · score 0.41
- osteopetrosis · score 0.37
- Abnormal bleeding · score 0.31
- neurodegenerative disease · score 0.28
- breast adenocarcinoma · score 0.26
- genetic disorder · score 0.19
- glioblastoma multiforme · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7LDG7-F1 | alphafold | PREDICTED | 77.09 | — |
Amino-acid sequence (609 residues)
MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS QLAAKLLHIY QQSRKDNSNS LQVKTCHLVR YWISAFPAEF DLNPELAEQI KELKALLDQE GNRRHSSLID IDSVPTYKWK RQVTQRNPVG QKKRKMSLLF DHLEPMELAE HLTYLEYRSF CKILFQDYHS FVTHGCTVDN PVLERFISLF NSVSQWVQLM ILSKPTAPQR ALVITHFVHV AEKLLQLQNF NTLMAVVGGL SHSSISRLKE THSHVSPETI KLWEGLTELV TATGNYGNYR RRLAACVGFR FPILGVHLKD LVALQLALPD WLDPARTRLN GAKMKQLFSI LEELAMVTSL RPPVQANPDL LSLLTVSLDQ YQTEDELYQL SLQREPRSKS SPTSPTSCTP PPRPPVLEEW TSAAKPKLDQ ALVVEHIEKM VESVFRNFDV DGDGHISQEE FQIIRGNFPY LSAFGDLDQN QDGCISREEM VSYFLRSSSV LGGRMGFVHN FQESNSLRPV ACRHCKALIL GIYKQGLKCR ACGVNCHKQC KDRLSVECRR RAQSVSLEGS APSPSPMHSH HHRAFSFSLP RPGRRGSRPP EIREEEVQTV EDGVFDIHL
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