About Ribonucleoside-diphosphate reductase subunit M2 B
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) is a protein
from Homo sapiens identified by UniProt accession
Q7LG56, 351 residues long.
MolForge cross-references it against 0 known binders and
297 disease associations.
Target properties
| Protein name | Ribonucleoside-diphosphate reductase subunit M2 B |
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| UniProt accession | Q7LG56 |
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| Gene | RRM2B |
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| Organism | Homo sapiens |
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| Length | 351 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (297)
Diseases linked to this target (Open Targets).
- Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy · score 0.82
- mitochondrial DNA depletion syndrome 8a · score 0.81
- mitochondrial dna depletion syndrome 8b (mngie type) · score 0.81
- progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 5 · score 0.73
- mitochondrial neurogastrointestinal encephalomyopathy · score 0.64
- rod-cone dystrophy, sensorineural deafness, and Fanconi-type renal dysfunction · score 0.57
- mitochondrial DNA depletion syndrome, encephalomyopathic form · score 0.54
- erythrocyte count · score 0.43
- blood protein measurement · score 0.42
- mitochondrial disease · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7LG56-F1 | alphafold | PREDICTED | 85.45 | — |
Amino-acid sequence (351 residues)
MGDPERPEAA GLDQDERSSS DTNESEIKSN EEPLLRKSSR RFVIFPIQYP DIWKMYKQAQ ASFWTAEEVD LSKDLPHWNK LKADEKYFIS HILAFFAASD GIVNENLVER FSQEVQVPEA RCFYGFQILI ENVHSEMYSL LIDTYIRDPK KREFLFNAIE TMPYVKKKAD WALRWIADRK STFGERVVAF AAVEGVFFSG SFAAIFWLKK RGLMPGLTFS NELISRDEGL HCDFACLMFQ YLVNKPSEER VREIIVDAVK IEQEFLTEAL PVGLIGMNCI LMKQYIEFVA DRLLVELGFS KVFQAENPFD FMENISLEGK TNFFEKRVSE YQRFAVMAET TDNVFTLDAD F
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