Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1)

About Heparan sulfate 2-O-sulfotransferase 1

Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) is a protein from Homo sapiens identified by UniProt accession Q7LGA3, 356 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Heparan sulfate 2-O-sulfotransferase 1
UniProt accession	Q7LGA3
Gene	HS2ST1
Organism	Homo sapiens
Length	356 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

neurofacioskeletal syndrome with or without renal agenesis · score 0.66
Intellectual disability · score 0.53
complex neurodevelopmental disorder · score 0.37
genetic disorder · score 0.19
mathematical ability · score 0.13
cortical surface area measurement · score 0.09
uveal coloboma-cleft lip and palate-intellectual disability · score 0.04
spondyloperipheral dysplasia · score 0.04
Klippel-Feil syndrome 3, autosomal dominant · score 0.04
Kniest dysplasia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7LGA3-F1	alphafold	PREDICTED	91.73	—

Amino-acid sequence (356 residues)

MGLLRIMMPP KLQLLAVVAF AVAMLFLENQ IQKLEESRSK LERAIARHEV REIEQRHTMD GPRQDATLDE EEDMVIIYNR VPKTASTSFT NIAYDLCAKN KYHVLHINTT KNNPVMSLQD QVRFVKNITS WKEMKPGFYH GHVSYLDFAK FGVKKKPIYI NVIRDPIERL VSYYYFLRFG DDYRPGLRRR KQGDKKTFDE CVAEGGSDCA PEKLWLQIPF FCGHSSECWN VGSRWAMDQA KYNLINEYFL VGVTEELEDF IMLLEAALPR FFRGATELYR TGKKSHLRKT TEKKLPTKQT IAKLQQSDIW KMENEFYEFA LEQFQFIRAH AVREKDGDLY ILAQNFFYEK IYPKSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards