About Carbohydrate sulfotransferase 3
Carbohydrate sulfotransferase 3 (CHST3) is a protein
from Homo sapiens identified by UniProt accession
Q7LGC8, 479 residues long.
MolForge cross-references it against 0 known binders and
210 disease associations.
Target properties
| Protein name | Carbohydrate sulfotransferase 3 |
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| UniProt accession | Q7LGC8 |
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| Gene | CHST3 |
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| Organism | Homo sapiens |
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| Length | 479 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (210)
Diseases linked to this target (Open Targets).
- spondyloepiphyseal dysplasia with congenital joint dislocations · score 0.81
- CHST3-related skeletal dysplasia · score 0.71
- body height · score 0.43
- Larsen syndrome · score 0.42
- Autosomal dominant Larsen syndrome · score 0.42
- vertebral disorder · score 0.39
- lumbar disc herniation · score 0.38
- Spondyloepiphyseal dysplasia and spondyloepimetaphyseal dysplasia · score 0.37
- Back pain · score 0.37
- musculoskeletal system disease · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7LGC8-F1 | alphafold | PREDICTED | 79.83 | — |
Amino-acid sequence (479 residues)
MEKGLTLPQD CRDFVHSLKM RSKYALFLVF VVIVFVFIEK ENKIISRVSD KLKQIPQALA DANSTDPALI LAENASLLSL SELDSAFSQL QSRLRNLSLQ LGVEPAMEAA GEEEEEQRKE EEPPRPAVAG PRRHVLLMAT TRTGSSFVGE FFNQQGNIFY LFEPLWHIER TVSFEPGGAN AAGSALVYRD VLKQLFLCDL YVLEHFITPL PEDHLTQFMF RRGSSRSLCE DPVCTPFVKK VFEKYHCKNR RCGPLNVTLA AEACRRKEHM ALKAVRIRQL EFLQPLAEDP RLDLRVIQLV RDPRAVLASR MVAFAGKYKT WKKWLDDEGQ DGLREEEVQR LRGNCESIRL SAELGLRQPA WLRGRYMLVR YEDVARGPLQ KAREMYRFAG IPLTPQVEDW IQKNTQAAHD GSGIYSTQKN SSEQFEKWRF SMPFKLAQVV QAACGPAMRL FGYKLARDAA ALTNRSVSLL EERGTFWVT
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