About Proton channel OTOP1
Proton channel OTOP1 (OTOP1) is a protein
from Homo sapiens identified by UniProt accession
Q7RTM1, 612 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Proton channel OTOP1 |
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| UniProt accession | Q7RTM1 |
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| Gene | OTOP1 |
|---|
| Organism | Homo sapiens |
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| Length | 612 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- physical activity measurement · score 0.14
- visual perception measurement · score 0.07
- Obesity · score 0.07
- chorea, childhood-onset, with psychomotor retardation · score 0.07
- spinocerebellar ataxia type 29 · score 0.04
- deafness · score 0.04
- hearing loss, autosomal dominant 80 · score 0.03
- hearing loss, autosomal dominant 77 · score 0.03
- benign paroxysmal torticollis of infancy · score 0.03
- spinocerebellar ataxia type 18 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7RTM1-F1 | alphafold | PREDICTED | 75.69 | — |
Amino-acid sequence (612 residues)
MLEGLGSPAS PRAAASASVA GSSGPAACSP PSSSAPRSPE SPAPRRGGVR ASVPQKLAEM LSSQYGLIVF VAGLLLLLAW AVHAAGVSKS DLLCFLTALM LLQLLWMLWY VGRSSAHRRL FRLKDTHAGA GWLRGSITLF AVITVILGCL KIGYFIGFSE CLSATEGVFP VTHSVHTLLQ VYFLWGHAKD IIQSFKTLER FGVIHSVFTN LLLWANGVLN ESKHQLNEHK ERLITLGFGN ITTVLDDHTP QCNCTPPTLC TAISHGIYYL YPFNIEYQIL ASTMLYVLWK NIGRKVDSHQ HQKMQFKSDG VMVGAVLGLT VLAATIAVVV VYLIHIGRSK TKSESALIMF YLYAITLLML MGAAGLAGIR IYRIDEKSLD ESKNPARKLD SDLLVGTASG SWLISWGSIL AILCAEGHPR YTWYNLPYSI LAIVEKYIQN LFIFESIHRE PEKLSEDIQT LRVVTVCNGN TMPLASSCPK SGGVARDVAP QGKDMPPAAN GNVCMRESHD KEEEKQEESS WGGSPSPVRL PRFLQGNAKR KVLRNIAAFL FLCNISLWIP PAFGCRPEYD NGLEEIVFGF EPWIIVVNLA MPFSIFYRMH AAASLFEVYC KI
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