About STE20-related kinase adapter protein alpha
STE20-related kinase adapter protein alpha (STRADA) is a protein
from Homo sapiens identified by UniProt accession
Q7RTN6, 431 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | STE20-related kinase adapter protein alpha |
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| UniProt accession | Q7RTN6 |
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| Gene | STRADA |
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| Organism | Homo sapiens |
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| Length | 431 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (122)
Diseases linked to this target (Open Targets).
- polyhydramnios, megalencephaly, and symptomatic epilepsy · score 0.77
- Rolandic epilepsy · score 0.45
- childhood epilepsy with centrotemporal spikes · score 0.45
- neurodegenerative disease · score 0.41
- breast adenocarcinoma · score 0.28
- Parkinson disease · score 0.27
- lysosomal storage disease · score 0.27
- multiple sclerosis · score 0.27
- Alzheimer disease · score 0.27
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7RTN6-F1 | alphafold | PREDICTED | 80.01 | — |
Amino-acid sequence (431 residues)
MSFLVSKPER IRRWVSEKFI VEGLRDLELF GEQPPGDTRR KTNDASSESI ASFSKQEVMS SFLPEGGCYE LLTVIGKGFE DLMTVNLARY KPTGEYVTVR RINLEACSNE MVTFLQGELH VSKLFNHPNI VPYRATFIAD NELWVVTSFM AYGSAKDLIC THFMDGMNEL AIAYILQGVL KALDYIHHMG YVHRSVKASH ILISVDGKVY LSGLRSNLSM ISHGQRQRVV HDFPKYSVKV LPWLSPEVLQ QNLQGYDAKS DIYSVGITAC ELANGHVPFK DMPATQMLLE KLNGTVPCLL DTSTIPAEEL TMSPSRSVAN SGLSDSLTTS TPRPSNGDSP SHPYHRTFSP HFHHFVEQCL QRNPDARPSA STLLNHSFFK QIKRRASEAL PELLRPVTPI TNFEGSQSQD HSGIFGLVTN LEELEVDDWE F
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