Magnesium transporter NIPA1 (NIPA1)

About Magnesium transporter NIPA1

Magnesium transporter NIPA1 (NIPA1) is a protein from Homo sapiens identified by UniProt accession Q7RTP0, 329 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	Magnesium transporter NIPA1
UniProt accession	Q7RTP0
Gene	NIPA1
Organism	Homo sapiens
Length	329 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (135)

Diseases linked to this target (Open Targets).

Autosomal dominant spastic paraplegia type 6 · score 0.75
hereditary spastic paraplegia 6 · score 0.74
hereditary spastic paraplegia · score 0.44
Spastic paraplegia · score 0.37
visual perception measurement · score 0.23
amyotrophic lateral sclerosis · score 0.19
genetic disorder · score 0.19
autosomal dominant complex spastic paraplegia · score 0.18
early-onset non-syndromic cataract · score 0.09
isolated ectopia lentis · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7RTP0-F1	alphafold	PREDICTED	85.29	—

Amino-acid sequence (329 residues)

MGTAAAAAAA AAAAAAGEGA RSPSPAAVSL GLGVAVVSSL VNGSTFVLQK KGIVRAKRRG TSYLTDIVWW AGTIAMAVGQ IGNFLAYTAV PTVLVTPLGA LGVPFGSILA SYLLKEKLNI LGKLGCLLSC AGSVVLIIHS PKSESVTTQA ELEEKLTNPV FVGYLCIVLL MLLLLIFWIA PAHGPTNIMV YISICSLLGS FTVPSTKGIG LAAQDILHNN PSSQRALCLC LVLLAVLGCS IIVQFRYINK ALECFDSSVF GAIYYVVFTT LVLLASAILF REWSNVGLVD FLGMACGFTT VSVGIVLIQV FKEFNFNLGE MNKSNMKTD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards