About NACHT, LRR and PYD domains-containing protein 9
NACHT, LRR and PYD domains-containing protein 9 (NLRP9) is a protein
from Homo sapiens identified by UniProt accession
Q7RTR0, 991 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | NACHT, LRR and PYD domains-containing protein 9 |
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| UniProt accession | Q7RTR0 |
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| Gene | NLRP9 |
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| Organism | Homo sapiens |
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| Length | 991 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- congenital stationary night blindness · score 0.12
- Abnormal jaw morphology · score 0.11
- congenital sucrase-isomaltase deficiency · score 0.05
- diarrhea-vomiting due to trehalase deficiency · score 0.05
- recurrent infections associated with rare immunoglobulin isotypes deficiency · score 0.05
- selective IgA deficiency disease · score 0.04
- lactose intolerance adult type · score 0.04
- pouchitis · score 0.04
- high density lipoprotein cholesterol measurement · score 0.04
- breast carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7RTR0-F1 | alphafold | PREDICTED | 90.20 | — |
Amino-acid sequence (991 residues)
MAESFFSDFG LLWYLKELRK EEFWKFKELL KQPLEKFELK PIPWAELKKA SKEDVAKLLD KHYPGKQAWE VTLNLFLQIN RKDLWTKAQE EMRNKLNPYR KHMKETFQLI WEKETCLHVP EHFYKETMKN EYKELNDAYT AAARRHTVVL EGPDGIGKTT LLRKVMLDWA EGNLWKDRFT FVFFLNVCEM NGIAETSLLE LLSRDWPESS EKIEDIFSQP ERILFIMDGF EQLKFNLQLK ADLSDDWRQR QPMPIILSSL LQKKMLPESS LLIALGKLAM QKHYFMLRHP KLIKLLGFSE SEKKSYFSYF FGEKSKALKV FNFVRDNGPL FILCHNPFTC WLVCTCVKQR LERGEDLEIN SQNTTYLYAS FLTTVFKAGS QSFPPKVNRA RLKSLCALAA EGIWTYTFVF SHGDLRRNGL SESEGVMWVG MRLLQRRGDC FAFMHLCIQE FCAAMFYLLK RPKDDPNPAI GSITQLVRAS VVQPQTLLTQ VGIFMFGIST EEIVSMLETS FGFPLSKDLK QEITQCLESL SQCEADREAI AFQELFIGLF ETQEKEFVTK VMNFFEEVFI YIGNIEHLVI ASFCLKHCQH LTTLRMCVEN IFPDDSGCIS DYNEKLVYWR ELCSMFITNK NFQILDMENT SLDDPSLAIL CKALAQPVCK LRKLIFTSVY FGHDSELFKA VLHNPHLKLL SLYGTSLSQS DIRHLCETLK HPMCKIEELI LGKCDISSEV CEDIASVLAC NSKLKHLSLV ENPLRDEGMT LLCEALKHSH CALERLMLMY CCLTSVSCDS ISEVLLCSKS LSLLDLGSNA LEDNGVASLC AALKHPGCSI RELWLMGCFL TSDSCKDIAA VLICNGKLKT LKLGHNEIGD TGVRQLCAAL QHPHCKLECL GLQTCPITRA CCDDIAAALI ACKTLRSLNL DWIALDADAV VVLCEALSHP DCALQMLGLH KSGFDEETQK ILMSVEEKIP HLTISHGPWI DEEYKIRGVL L
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