Class A basic helix-loop-helix protein 15 (BHLHA15)

About Class A basic helix-loop-helix protein 15

Class A basic helix-loop-helix protein 15 (BHLHA15) is a protein from Homo sapiens identified by UniProt accession Q7RTS1, 189 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	Class A basic helix-loop-helix protein 15
UniProt accession	Q7RTS1
Gene	BHLHA15
Organism	Homo sapiens
Length	189 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (124)

Diseases linked to this target (Open Targets).

prostate carcinoma · score 0.24
type 2 diabetes mellitus · score 0.17
urate measurement · score 0.16
serum gamma-glutamyl transferase measurement · score 0.15
neuroticism measurement · score 0.12
cancer · score 0.10
uric acid measurement · score 0.10
neoplasm · score 0.09
hepatocellular carcinoma · score 0.08
melanoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7RTS1-F1	alphafold	PREDICTED	68.74	—

Amino-acid sequence (189 residues)

MKTKNRPPRR RAPVQDTEAT PGEGTPDGSL PNPGPEPAKG LRSRPARAAA RAPGEGRRRR PGPSGPGGRR DSSIQRRLES NERERQRMHK LNNAFQALRE VIPHVRADKK LSKIETLTLA KNYIKSLTAT ILTMSSSRLP GLEGPGPKLY QHYQQQQQVA GGALGATEAQ PQGHLQRYST QIHSFREGT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards