About Proton channel OTOP2
Proton channel OTOP2 (OTOP2) is a protein
from Homo sapiens identified by UniProt accession
Q7RTS6, 562 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Proton channel OTOP2 |
|---|
| UniProt accession | Q7RTS6 |
|---|
| Gene | OTOP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 562 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (24)
Diseases linked to this target (Open Targets).
- Usher syndrome type 1 · score 0.47
- Usher syndrome · score 0.46
- intraocular pressure measurement · score 0.18
- genetic disorder · score 0.17
- colorectal carcinoma · score 0.07
- colorectal adenocarcinoma · score 0.05
- ulcerative colitis · score 0.05
- esophageal squamous cell carcinoma · score 0.03
- esophageal adenocarcinoma · score 0.03
- colorectal cancer · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7RTS6-F1 | alphafold | PREDICTED | 77.98 | — |
Amino-acid sequence (562 residues)
MSEELAQGPK ESPPAPRAGP REVWKKGGRL LSVLLAVNVL LLACTLISGG AFNKVAVYDT DVFALLTAMM LLATLWILFY LLRTVRCPCA VPYRDAHAGP IWLRGGLVLF GICTLIMDVF KTGYYSSFFE CQSAIKILHP LIQAVFVIIQ TYFLWVSAKD CVHVHLDLTW CGLMFTLTTN LAIWMAAVVD ESVHQSHSYS SSHSNASHAR LISDQHADNP VGGDSCLCST AVCQIFQQGY FYLYPFNIEY SLFASTMLYV MWKNVGRFLA STPGHSHTPT PVSLFRETFF AGPVLGLLLF VVGLAVFIIY EVQVSGDGSR TRQALVIYYS FNIVCLGLTT LVSLSGSIIY RFDRRAMDHH KNPTRTLDVA LLMGAALGQY AISYYSIVAV VAGTPQDLLA GLNLTHALLM IAQHTFQNMF IIESLHRGPP GAEPHSTHPK EPCQDLTFTN LDALHTLSAC PPNPGLVSPS PSDQREAVAI VSTPRSQWRR QCLKDISLFL LLCNVILWIM PAFGARPHFS NTVEVDFYGY SLWAVIVNIC LPFGIFYRMH AVSSLLEVYV LS
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