Oligodendrocyte transcription factor 3 (OLIG3)

About Oligodendrocyte transcription factor 3

Oligodendrocyte transcription factor 3 (OLIG3) is a protein from Homo sapiens identified by UniProt accession Q7RTU3, 272 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Oligodendrocyte transcription factor 3
UniProt accession	Q7RTU3
Gene	OLIG3
Organism	Homo sapiens
Length	272 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
rheumatoid arthritis · score 0.37
celiac disease · score 0.36
ulcerative colitis · score 0.36
inflammatory bowel disease · score 0.34
autoimmune disease · score 0.31
systolic blood pressure · score 0.31
neutrophil percentage of leukocytes · score 0.31
lymphocyte percentage of leukocytes · score 0.29
asthma · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7RTU3-F1	alphafold	PREDICTED	62.72	—

Amino-acid sequence (272 residues)

MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHQESRLNSV SSTQGDMMQK MPGESLSRAG AKAAGESSKY KIKKQLSEQD LQQLRLKING RERKRMHDLN LAMDGLREVM PYAHGPSVRK LSKIATLLLA RNYILMLTSS LEEMKRLVGE IYGGHHSAFH CGTVGHSAGH PAHAANSVHP VHPILGGALS SGNASSPLSA ASLPAIGTIR PPHSLLKAPS TPPALQLGSG FQHWAGLPCP CTICQMPPPP HLSALSTANM ARLSAESKDL LK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards