Class A basic helix-loop-helix protein 9 (BHLHA9)

About Class A basic helix-loop-helix protein 9

Class A basic helix-loop-helix protein 9 (BHLHA9) is a protein from Homo sapiens identified by UniProt accession Q7RTU4, 235 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Class A basic helix-loop-helix protein 9
UniProt accession	Q7RTU4
Gene	BHLHA9
Organism	Homo sapiens
Length	235 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

mesoaxial synostotic syndactyly with phalangeal reduction · score 0.73
split hand-foot malformation 1 with sensorineural hearing loss · score 0.55
Split hand - split foot - deafness · score 0.55
Camptosynpolydactyly, complex · score 0.44
chromosome 17P13.3, telomeric, duplication syndrome · score 0.38
Tibial aplasia - ectrodactyly · score 0.37
polydactyly · score 0.37
Polydactyly · score 0.37
genetic disorder · score 0.19
syndactyly type 1 · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7RTU4-F1	alphafold	PREDICTED	64.67	—

Amino-acid sequence (235 residues)

MLRGAPGLGL TARKGAEDSA EDLGGPCPEP GGDSGVLGAN GASCSRGEAE EPAGRRRARP VRSKARRMAA NVRERKRILD YNEAFNALRR ALRHDLGGKR LSKIATLRRA IHRIAALSLV LRASPAPRGP CGHLECHGPA ARGDTGDTGA SPPPPAGPSL ARPDAARPSV PSAPRCASCP PHAPLARPSA VAEGPGLAQA SGGSWRRCPG ASSAGPPPWP RGYLRSAPGM GHPRS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards