About Taste receptor type 1 member 1
Taste receptor type 1 member 1 (TAS1R1) is a protein
from Homo sapiens identified by UniProt accession
Q7RTX1, 841 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Taste receptor type 1 member 1 |
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| UniProt accession | Q7RTX1 |
|---|
| Gene | TAS1R1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 841 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- body height · score 0.24
- glioblastoma multiforme · score 0.21
- ovarian cancer · score 0.18
- lung adenocarcinoma · score 0.18
- HbA1c measurement · score 0.16
- breast adenocarcinoma · score 0.16
- squamous cell lung carcinoma · score 0.13
- head and neck squamous cell carcinoma · score 0.13
- mean reticulocyte volume · score 0.11
- gastric adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7RTX1-F1 | alphafold | PREDICTED | 88.38 | — |
Amino-acid sequence (841 residues)
MLLCTARLVG LQLLISCCWA FACHSTESSP DFTLPGDYLL AGLFPLHSGC LQVRHRPEVT LCDRSCSFNE HGYHLFQAMR LGVEEINNST ALLPNITLGY QLYDVCSDSA NVYATLRVLS LPGQHHIELQ GDLLHYSPTV LAVIGPDSTN RAATTAALLS PFLVPMISYA ASSETLSVKR QYPSFLRTIP NDKYQVETMV LLLQKFGWTW ISLVGSSDDY GQLGVQALEN QATGQGICIA FKDIMPFSAQ VGDERMQCLM RHLAQAGATV VVVFSSRQLA RVFFESVVLT NLTGKVWVAS EAWALSRHIT GVPGIQRIGM VLGVAIQKRA VPGLKAFEEA YARADKKAPR PCHKGSWCSS NQLCRECQAF MAHTMPKLKA FSMSSAYNAY RAVYAVAHGL HQLLGCASGA CSRGRVYPWQ LLEQIHKVHF LLHKDTVAFN DNRDPLSSYN IIAWDWNGPK WTFTVLGSST WSPVQLNINE TKIQWHGKDN QVPKSVCSSD CLEGHQRVVT GFHHCCFECV PCGAGTFLNK SDLYRCQPCG KEEWAPEGSQ TCFPRTVVFL ALREHTSWVL LAANTLLLLL LLGTAGLFAW HLDTPVVRSA GGRLCFLMLG SLAAGSGSLY GFFGEPTRPA CLLRQALFAL GFTIFLSCLT VRSFQLIIIF KFSTKVPTFY HAWVQNHGAG LFVMISSAAQ LLICLTWLVV WTPLPAREYQ RFPHLVMLEC TETNSLGFIL AFLYNGLLSI SAFACSYLGK DLPENYNEAK CVTFSLLFNF VSWIAFFTTA SVYDGKYLPA ANMMAGLSSL SSGFGGYFLP KCYVILCRPD LNSTEHFQAS IQDYTRRCGS T
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