About Cation channel sperm-associated protein 4
Cation channel sperm-associated protein 4 (CATSPER4) is a protein
from Homo sapiens identified by UniProt accession
Q7RTX7, 472 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Cation channel sperm-associated protein 4 |
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| UniProt accession | Q7RTX7 |
|---|
| Gene | CATSPER4 |
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| Organism | Homo sapiens |
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| Length | 472 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (98)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.26
- cutaneous melanoma · score 0.25
- lung adenocarcinoma · score 0.23
- lymphocyte count · score 0.22
- breast adenocarcinoma · score 0.16
- squamous cell lung carcinoma · score 0.15
- glioblastoma multiforme · score 0.15
- head and neck squamous cell carcinoma · score 0.13
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7RTX7-F1 | alphafold | PREDICTED | 68.00 | — |
Amino-acid sequence (472 residues)
MRDNEKAWWQ QWTSHTGLEG WGGTQEDRMG FGGAVAALRG RPSPLQSTIH ESYGRPEEQV LINRQEITNK ADAWDMQEFI THMYIKQLLR HPAFQLLLAL LLVINAITIA LRTNSYLDQK HYELFSTIDD IVLTILLCEV LLGWLNGFWI FWKDGWNILN FIIVFILLLR FFINEINIPS INYTLRALRL VHVCMAVEPL ARIIRVILQS VPDMANIMVL ILFFMLVFSV FGVTLFGAFV PKHFQNIQVA LYTLFICITQ DGWVDIYSDF QTEKREYAME IGGAIYFTIF ITIGAFIGIN LFVIVVTTNL EQMMKAGEQG QQQRITFSET GAEEEEENDQ LPLVHCVVAR SEKSGLLQEP LAGGPLSNLS ENTCDNFCLV LEAIQENLRQ YKEIRDELNM IVEEVRAIRF NQEQESEVLN RRSSTSGSLE TTSSKDIRQM SQQQDLLSAL VSMEKVHDSS SQILLKKHKS SH
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