About Transmembrane protease serine 7
Transmembrane protease serine 7 (TMPRSS7) is a protein
from Homo sapiens identified by UniProt accession
Q7RTY8, 843 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Transmembrane protease serine 7 |
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| UniProt accession | Q7RTY8 |
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| Gene | TMPRSS7 |
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| Organism | Homo sapiens |
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| Length | 843 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- drug use measurement · score 0.09
- atrial fibrillation · score 0.03
- glucuronate measurement · score 0.02
- neoplasm · score 0.01
- subarachnoid hemorrhage · score 0.01
- cancer · score 0.00
- Invasive Breast Carcinoma · score 0.00
- hyperuricemia · score 0.00
- chronic kidney disease · score 0.00
- Hypertriglyceridemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7RTY8-F1 | alphafold | PREDICTED | 80.36 | — |
Amino-acid sequence (843 residues)
MDKENSDVSA APADLKISNI SVQVVSAQKK LPVRRPPLPG RRLPLPGRRP PQRPIGKAKP KKQSKKKVPF WNVQNKIILF TVFLFILAVI AWTLLWLYIS KTESKDAFYF AGMFRITNIE FLPEYRQKES REFLSVSRTV QQVINLVYTT SAFSKFYEQS VVADVSSNNK GGLLVHFWIV FVMPRAKGHI FCEDCVAAIL KDSIQTSIIN RTSVGSLQGL AVDMDSVVLN AGLRSDYSST IGSDKGCSQY FYAEHLSLHY PLEISAASGR LMCHFKLVAI VGYLIRLSIK SIQIEADNCV TDSLTIYDSL LPIRSSILYR ICEPTRTLMS FVSTNNLMLV TFKSPHIRRL SGIRAYFEVI PEQKCENTVL VKDITGFEGK ISSPYYPSYY PPKCKCTWKF QTSLSTLGIA LKFYNYSITK KSMKGCEHGW WEINEHMYCG SYMDHQTIFR VPSPLVHIQL QCSSRLSDKP LLAEYGSYNI SQPCPVGSFR CSSGLCVPQA QRCDGVNDCF DESDELFCVS PQPACNTSSF RQHGPLICDG FRDCENGRDE QNCTQSIPCN NRTFKCGNDI CFRKQNAKCD GTVDCPDGSD EEGCTCSRSS SALHRIIGGT DTLEGGWPWQ VSLHFVGSAY CGASVISREW LLSAAHCFHG NRLSDPTPWT AHLGMYVQGN AKFVSPVRRI VVHEYYNSQT FDYDIALLQL SIAWPETLKQ LIQPICIPPT GQRVRSGEKC WVTGWGRRHE ADNKGSLVLQ QAEVELIDQT LCVSTYGIIT SRMLCAGIMS GKRDACKGDS GGPLSCRRKS DGKWILTGIV SWGHGSGRPN FPGVYTRVSN FVPWIHKYVP SLL
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