About Phospholipid phosphatase-related protein type 4
Phospholipid phosphatase-related protein type 4 (PLPPR4) is a protein
from Homo sapiens identified by UniProt accession
Q7Z2D5, 763 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Phospholipid phosphatase-related protein type 4 |
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| UniProt accession | Q7Z2D5 |
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| Gene | PLPPR4 |
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| Organism | Homo sapiens |
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| Length | 763 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (75)
Diseases linked to this target (Open Targets).
- urinary metabolite measurement · score 0.30
- psychotic symptoms · score 0.24
- ovarian cancer · score 0.23
- low grade glioma · score 0.12
- breast adenocarcinoma · score 0.10
- prostate adenocarcinoma · score 0.10
- lung adenocarcinoma · score 0.10
- thyroid gland adenocarcinoma · score 0.10
- smoking status measurement · score 0.04
- temporal lobe epilepsy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z2D5-F1 | alphafold | PREDICTED | 55.89 | — |
Amino-acid sequence (763 residues)
MQRAGSSGGR GECDISGAGR LGLEEAARLS CAVHTSPGGG RRPGQAAGMS AKERPKGKVI KDSVTLLPCF YFVELPILAS SVVSLYFLEL TDVFKPVHSG FSCYDRSLSM PYIEPTQEAI PFLMLLSLAF AGPAITIMVG EGILYCCLSK RRNGVGLEPN INAGGCNFNS FLRRAVRFVG VHVFGLCSTA LITDIIQLST GYQAPYFLTV CKPNYTSLNV SCKENSYIVE DICSGSDLTV INSGRKSFPS QHATLAAFAA VYVSMYFNST LTDSSKLLKP LLVFTFIICG IICGLTRITQ YKNHPVDVYC GFLIGGGIAL YLGLYAVGNF LPSDESMFQH RDALRSLTDL NQDPNRLLSA KNGSSSDGIA HTEGILNRNH RDASSLTNLK RANADVEIIT PRSPMGKENM VTFSNTLPRA NTPSVEDPVR RNASIHASMD SARSKQLLTQ WKNKNESRKL SLQVIEPEPG QSPPRSIEMR SSSEPSRVGV NGDHHGPGNQ YLKIQPGAVP GCNNSMPGGP RVSIQSRPGS SQLVHIPEET QENISTSPKS SSARAKWLKA AEKTVACNRS NSQPRIMQVI AMSKQQGVLQ SSPKNTEGST VSCTGSIRYK TLTDHEPSGI VRVEAHPENN RPIIQIPSTE GEGSGSWKWK APEKGSLRQT YELNDLNRDS ESCESLKDSF GSGDRKRSNI DSNEHHHHGI TTIRVTPVEG SEIGSETLSI SSSRDSTLRR KGNIILIPER SNSPENTRNI FYKGTSPTRA YKD
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