About Aprataxin
Aprataxin (APTX) is a protein
from Homo sapiens identified by UniProt accession
Q7Z2E3, 356 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Aprataxin |
|---|
| UniProt accession | Q7Z2E3 |
|---|
| Gene | APTX |
|---|
| Organism | Homo sapiens |
|---|
| Length | 356 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (103)
Diseases linked to this target (Open Targets).
- ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia · score 0.82
- Ataxia - oculomotor apraxia type 1 · score 0.79
- genetic disorder · score 0.47
- Dystonia · score 0.46
- epilepsy · score 0.34
- reticulocyte count · score 0.22
- PHF-tau measurement · score 0.20
- spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 · score 0.18
- reticulocyte measurement · score 0.17
- age at menopause · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z2E3-F1 | alphafold | PREDICTED | 80.76 | — |
Amino-acid sequence (356 residues)
MSNVNLSVSD FWRVMMRVCW LVRQDSRHQR IRLPHLEAVV IGRGPETKIT DKKCSRQQVQ LKAECNKGYV KVKQVGVNPT SIDSVVIGKD QEVKLQPGQV LHMVNELYPY IVEFEEEAKN PGLETHRKRK RSGNSDSIER DAAQEAEAGT GLEPGSNSGQ CSVPLKKGKD APIKKESLGH WSQGLKISMQ DPKMQVYKDE QVVVIKDKYP KARYHWLVLP WTSISSLKAV AREHLELLKH MHTVGEKVIV DFAGSSKLRF RLGYHAIPSM SHVHLHVISQ DFDSPCLKNK KHWNSFNTEY FLESQAVIEM VQEAGRVTVR DGMPELLKLP LRCHECQQLL PSIPQLKEHL RKHWTQ
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