About G protein-regulated inducer of neurite outgrowth 1
G protein-regulated inducer of neurite outgrowth 1 (GPRIN1) is a protein
from Homo sapiens identified by UniProt accession
Q7Z2K8, 1008 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | G protein-regulated inducer of neurite outgrowth 1 |
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| UniProt accession | Q7Z2K8 |
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| Gene | GPRIN1 |
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| Organism | Homo sapiens |
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| Length | 1008 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- gonorrhea · score 0.07
- lung adenocarcinoma · score 0.07
- hemochromatosis type 5 · score 0.05
- FTH1-related iron overload · score 0.05
- non-small cell lung carcinoma · score 0.03
- hereditary hyperferritinemia with congenital cataracts · score 0.03
- neoplasm · score 0.03
- hepatocellular carcinoma · score 0.03
- Ataxia-telangiectasia · score 0.02
- esophageal squamous cell carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z2K8-F1 | alphafold | PREDICTED | 43.72 | — |
Amino-acid sequence (1008 residues)
MDTAEDPAWL QLLQKDSSPP GPRPTAFFCP QDGSLGAGSS AMRDYCPSQQ KASPAPPRHT PDQSPGMESR HRSPSGAGEG ASCSDGPRGS LACPSPTCFS PQESPSKETL EAHGASISGT PEATTSGKPE PVSSVKTEPK SSDDRNPMFL EKMDFKSSKQ ADSTSIGKED PGSSRKADPM FTGKAEPEIL GKGDPVAPGR MDPMTVRKED LGSLGKVDPL CSSKTYTVSP RKEDPGSLRK VDPVSSDKVD PVFPRKEEPR YSGKEHPVSS EKVAPTSAEK VDLVLSGKRD PGPSGKADPM PLESMDSAST GKTEPGLLGK LIPGSSGKNG PVSSGTGAPG SLGRLDPTCL GMADPASVGN VETVPATKED SRFLGKMDPA SSGEGRPVSG HTDTTASAKT DLTSLKNVDP MSSGKVDPVS LGKMDPMCSG KPELLSPGQA ERVSVGKAGT VSPGKEDPVS SRREDPISAG SRKTSSEKVN PESSGKTNPV SSGPGDPRSL GTAGPPSAVK AEPATGGKGD PLSSEKAGLV ASGKAAPTAS GKAEPLAVGK EDPVSKGKAD AGPSGQGDSV SIGKVVSTPG KTVPVPSGKV DPVSLGKAEA IPEGKVGSLP LEKGSPVTTT KADPRASGKA QPQSGGKAET KLPGQEGAAA PGEAGAVCLK KETPQASEKV DPGSCRKAEP LASGKGEPVS LGKADSAPSR KTESPSLGKV VPLSLEKTKP SSSSRQLDRK ALGSARSPEG ARGSEGRVEP KAEPVSSTEA SSLGQKDLEA AGAERSPCPE AAAPPPGPRT RDNFTKAPSW EASAPPPPRE DAGTQAGAQA CVSVAVSPMS PQDGAGGSAF SFQAAPRAPS PPSRRDAGLQ VSLGAAETRS VATGPMTPQA AAPPAFPEVR VRPGSALAAA VAPPEPAEPV RDVSWDEKGM TWEVYGAAME VEVLGMAIQK HLERQIEEHG RQGAPAPPPA ARAGPGRSGS VRTAPPDGAA KRPPGLFRAL LQSVRRPRCC SRAGPTAE
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